Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function

Table 5 P-values of genetic association study for candidate SNPs with lent LVDD trait: ICA and 14 echocardiography-derived endophenotypes.

Locus	Gene context	ICA E61	Risk allele	Echocardiography-derived LVDF endophenotypes
				E	A	E/A	DT	IVRT	E'_sep	E'_lat	E'_gl	E/E'_sep	E/E'_lat	E/E'_gl	A'_sep	A'_lat	A'_gl
*PPARGC1A*
rs12500214	I-2				0.01					0.02	0.04				0.026	0.028	0.009
rs3736265	E-9						0.03
rs3755862	I-7	0.038	A				0.03
rs3774902	I-1	0.034	T
rs3774921	I-10			0.021
rs768695	I-12															0.011	0.018
rs7672915	I-2											0.049
rs7677000	I-2									0.04
*PPARA*
rs4253623	I-1A	0.045	G				0.04
rs4253655	I-B															0.028	0.043
rs4253681	I-2A	0.039	C												0.005		0.009
rs4253725	I-3			0.042												0.044
rs4253760	I-6	0.021	G				0.04						0.02
rs4253765	I-6	0.02	C										0.02
*PPARG*
rs1797912	I-1											0.026
rs2972162	I-4				0.04								0.02	0.029
rs3856806	E-7	0.006	T

ISSN: 1471-2350