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Table 4 TNF-α haplotypes and risk of HIV-1-infection.

From: Effect of TNF-α genetic variants and CCR5Δ32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards

Haplotypes

TNF-αSNP

n (estimated frequencies in %)

OR

OR 95CI%

pvalue *

 

-238 G>A

-308 G>A

-863 G>A

Total

(n = 373)

Uninfected

(n = 189)1

HIV-1-Infected

(n = 184)

   

H1

G

G

C

246 (65.98%)

115 (61.45%)

131 (70.73%)

1.00

  

H2

G

G

A

54 (14.46%)

31 (16.66%)

23 (12.51%)

1.47

0.95 - 2.30

0.09

H3

G

A

C

48 (13.07%)

29 (15.36%)

19 (10.45%)

1.65

1.04 - 2.64

0.04

H4

A

G

C

21 (5.45%)

10 (5.13%)

11 (5.99%)

1.03

0.52 - 2.04

0.94

rare

*

*

*

5 (1.04%)

-

-

1.46

0.23 - 9.47

0.69

  1. Note: The exposed uninfected subset of patients could not be included in the analysis because of the low number of individuals available.
  2. 1Of 203 healthy uninfected controls individuals, only 189 had the three TNF-α SNPs assessed.
  3. * p value for comparisons of each haplotype with a frequency greater than 1% with the most common haplotype (H1)
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BMC Medical Genetics

ISSN: 1471-2350

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