MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1Cand impaired beta-cell function in Chinese Hans from Shanghai

Table 2 Associations of rs10830963 with fasting glucose, HbA_1C, HOMA-B and HOMA-S.

*MTNR1B*rs10830963	Beijing (1389)		Shanghai (1497)		Total population (2886)		Pfor Interaction
	beta (SE)	P _add	beta (SE)	P _add	beta (SE)	P _add	SNP × Region	SNP × Sleep duration	SNP × Sleep disorder
Glucose(mmol/l)
Model 1	-0.03 (0.06)	0.59	0.11 (0.04)	0.005	0.04 (0.07)	0.51	0.05	0.35	0.48
Model 2	-0.03 (0.05)	0.58	0.11 (0.04)	0.005	0.04 (0.07)	0.52
Model 3	-0.03 (0.06)	0.59	0.11 (0.04)	0.005	0.04 (0.07)	0.51
HbA_1C (%)
Model 1	-0.003 (0.04)	0.93	0.07 (0.02)	0.004	0.04 (0.04)	0.30	0.09	0.52	0.22
Model 2	-0.004 (0.04)	0.92	0.07 (0.03)	0.004	0.04 (0.04)	0.31
Model 3	-0.004 (0.04)	0.93	0.07 (0.03)	0.004	0.04 (0.04)	0.30
HOMA-B (%)
Model 1	0.88 (1.58)	0.58	-5.01 (1.65)	0.003	-2.04 (2.94)	0.49	0.01	0.75	0.34
Model 2	0.91 (1.57)	0.56	-5.01 (1.65)	0.003	-2.02 (2.96)	0.49
Model 3	0.88 (1.58)	0.58	-5.01 (1.65)	0.003	-2.04 (2.94)	0.49
Log-transformed	HOMA-S (%)
Model 1	-0.004 (0.02)	0.82	0.008 (0.02)	0.66	0.002 (0.01)	0.86	0.65	0.31	0.73
Model 2	-0.005 (0.02)	0.82	0.008 (0.02)	0.66	0.002 (0.01)	0.86
Model 3	-0.004 (0.02)	0.82	0.008 (0.02)	0.66	0.002 (0.01)	0.86

Participants previously diagnosed with type 2 diabetes or receiving glucose-lowering treatment (n = 264) were excluded from the analyses. HOMA-S values were log-transformed before analyses. P values and beta (SE) for Beijing and Shanghai subpopulations were calculated using linear regression model assuming an additive model. The combined P values and beta (SE) were calculated in meta-analyses using random model.
Model 1: Adjusted for age, sex and BMI.
Model 2: Adjusted variables in model 1 plus sleep duration.
Model 3: Adjusted variables in model 1 plus self-reported sleep disorder.
P values for interaction were tested in linear regression model using terms of SNP × Region (Beijing/Shanghai), SNP × Sleep duration or SNP × Sleep disorder.

ISSN: 1471-2350