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Table 2 Anthrometric characteristics in obese and normal-weight children and adolescents stratified according to TMEM18 rs6548238 and rs7561317 genotype.

From: The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children

rs6548238 CC CT TT P
Normal-weight, n = 523     
Age (years) 17.1 ± 0.9 16.9 ± 0.8 17.0 ± 0.5 0.126
Weight (kg) 63.5 ± 9.9 63.5 ± 10.1 65.2 ± 9.6 0.247
Length (m) 1.73 ± 0.08 1.73 ± 0.09 1.73 ± 0.09 0.651
BMI SDS 0.139 ± 0.565 0.184 ± 0.630 0.158 ± 0.375 0.921
Obese, n = 500     
Age (years) 12.2 ± 3.3 12.6 ± 2.9 13.2 ± 2.5 0.203
Birth length (cm) 50.0 ± 2.9 50.4 ± 2.5 52.1 ± 1.6 0.048
Birth weight (g) 3465 ± 721 3627 ± 641 3879 ± 225 0.077
Length (m) 1.66 ± 0.14 1.58 ± 0.16 1.58 ± 0.18 0.674
Weight (kg) 109.6 ± 31.5 90.4 ± 28.5 91.5 ± 29.1 0.920
BMI SDS 6.3 ± 0.9 5.5 ± 1.6 5.8 ± 1.5 0.073
P-Glucose (mmol/l) 4.5 ± 0.7 4.3 ± 0.6 4.4 ± 0.9 0.512
fS-Insulin (mmol/l) 118.2 ± 71.3 113.8 ± 74.5 92.6 ± 44.3 0.503
Triglycerides (mmol/l) 0.82 ± 0.81 0.82 ± 0.97 0.57 ± 0.53 0.944
Cholesterol (mmol/l) 3.73 ± 0.85 3.84 ± 0.86 3.43 ± 0.53 0.482
rs7561317 GG GA AA P
Normal-weight, n = 523     
Age (years) 17.1 ± 0.9 16.9 ± 0.8 17.1 ± 0.5 0.175
Weight (kg) 63.4 ± 9.9 63.6 ± 9.9 65.2 ± 9.6 0.335
Length (m) 1.72 ± 0.09 1.73 ± 0.09 1.73 ± 0.09 0.708
BMI SDS 0.139 ± 0.567 0.181 ± 0.629 0.158 ± 0.374 0.780
Obese, n = 500     
Age (years) 12.2 ± 3.3 12.6 ± 2.9 13.3 ± 2.5 0.191
Birth length (cm) 49.9 ± 2.9 50.4 ± 2.4 52.1 ± 1.6 0.032
Birth weight (g) 3469 ± 723 3614 ± 644 3879 ± 225 0.121
Length (m) 1.66 ± 0.14 1.58 ± 0.16 1.58 ± 0.18 0.792
Weight (kg) 109.6 ± 31.5 90.1 ± 27.8 91.5 ± 29.3 0.859
BMI SDS 6.3 ± 0.9 5.5 ± 1.6 5.8 ± 1.5 0.038
P-Glucose (mmol/l) 4.5 ± 0.7 4.3 ± 0.6 4.4 ± 0.9 0.362
fS-Insulin (mmol/l) 117.7 ± 71.4 115.4 ± 74.6 92.6 ± 44.3 0.713
Triglycerides (mmol/l) 0.82 ± 0.80 0.81 ± 0.96 0.57 ± 0.53 0.882
Cholesterol (mmol/l) 3.73 ± 0.86 3.83 ± 0.86 3.43 ± 0.53 0.683
  1. Data are means and SD divided into genotype groups. P indicates p-values adjusted for
  2. significant covariates.