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Table 2 Anthrometric characteristics in obese and normal-weight children and adolescents stratified according to TMEM18 rs6548238 and rs7561317 genotype.

From: The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children

rs6548238

CC

CT

TT

P

Normal-weight, n = 523

    

Age (years)

17.1 ± 0.9

16.9 ± 0.8

17.0 ± 0.5

0.126

Weight (kg)

63.5 ± 9.9

63.5 ± 10.1

65.2 ± 9.6

0.247

Length (m)

1.73 ± 0.08

1.73 ± 0.09

1.73 ± 0.09

0.651

BMI SDS

0.139 ± 0.565

0.184 ± 0.630

0.158 ± 0.375

0.921

Obese, n = 500

    

Age (years)

12.2 ± 3.3

12.6 ± 2.9

13.2 ± 2.5

0.203

Birth length (cm)

50.0 ± 2.9

50.4 ± 2.5

52.1 ± 1.6

0.048

Birth weight (g)

3465 ± 721

3627 ± 641

3879 ± 225

0.077

Length (m)

1.66 ± 0.14

1.58 ± 0.16

1.58 ± 0.18

0.674

Weight (kg)

109.6 ± 31.5

90.4 ± 28.5

91.5 ± 29.1

0.920

BMI SDS

6.3 ± 0.9

5.5 ± 1.6

5.8 ± 1.5

0.073

P-Glucose (mmol/l)

4.5 ± 0.7

4.3 ± 0.6

4.4 ± 0.9

0.512

fS-Insulin (mmol/l)

118.2 ± 71.3

113.8 ± 74.5

92.6 ± 44.3

0.503

Triglycerides (mmol/l)

0.82 ± 0.81

0.82 ± 0.97

0.57 ± 0.53

0.944

Cholesterol (mmol/l)

3.73 ± 0.85

3.84 ± 0.86

3.43 ± 0.53

0.482

rs7561317

GG

GA

AA

P

Normal-weight, n = 523

    

Age (years)

17.1 ± 0.9

16.9 ± 0.8

17.1 ± 0.5

0.175

Weight (kg)

63.4 ± 9.9

63.6 ± 9.9

65.2 ± 9.6

0.335

Length (m)

1.72 ± 0.09

1.73 ± 0.09

1.73 ± 0.09

0.708

BMI SDS

0.139 ± 0.567

0.181 ± 0.629

0.158 ± 0.374

0.780

Obese, n = 500

    

Age (years)

12.2 ± 3.3

12.6 ± 2.9

13.3 ± 2.5

0.191

Birth length (cm)

49.9 ± 2.9

50.4 ± 2.4

52.1 ± 1.6

0.032

Birth weight (g)

3469 ± 723

3614 ± 644

3879 ± 225

0.121

Length (m)

1.66 ± 0.14

1.58 ± 0.16

1.58 ± 0.18

0.792

Weight (kg)

109.6 ± 31.5

90.1 ± 27.8

91.5 ± 29.3

0.859

BMI SDS

6.3 ± 0.9

5.5 ± 1.6

5.8 ± 1.5

0.038

P-Glucose (mmol/l)

4.5 ± 0.7

4.3 ± 0.6

4.4 ± 0.9

0.362

fS-Insulin (mmol/l)

117.7 ± 71.4

115.4 ± 74.6

92.6 ± 44.3

0.713

Triglycerides (mmol/l)

0.82 ± 0.80

0.81 ± 0.96

0.57 ± 0.53

0.882

Cholesterol (mmol/l)

3.73 ± 0.86

3.83 ± 0.86

3.43 ± 0.53

0.683

  1. Data are means and SD divided into genotype groups. P indicates p-values adjusted for
  2. significant covariates.