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Table 1 Association study of TMEM18 rs6548238 and rs7561317 variants with obesity

From: The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children

  n Genotype, n (%) MAF, % OR (95% CI) P HWE
   11 12 22     
rs6548238   CC CT TT     
Normal weight 523 356 (68) 148 (28) 19 (4) 18    0.461
Obese 500 378 (76) 115 (23) 7 (1) 13 1.450 (1.137-1.850) 0.002 0.586
rs7561317   GG GA AA     
Normal weight 523 348 (67) 156 (30) 19 (4) 19   0.001 0.770
Obese 499 375 (75) 117 (23) 7 (1) 13 1.507 (1.184-1.918)   0.530
  1. Data are number of subjects in each group and number of subjects for each genotype (% in each group). Minor allele frequency (MAF) for each group is given as percentage. Odds ratio (OR) with a 95% confidence interval (CI) was calculated assuming an additive model. Association with obesity was determined comparing subjects with normal weight and with obesity. P indicates p-values adjusted for sex. HWE indicates p-values for deviation from Hardy-Weinberg Equilibrium.