The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children

Table 1 Association study of TMEM18 rs6548238 and rs7561317 variants with obesity

	n	Genotype, n (%)			MAF, %	OR (95% CI)	P	HWE
		11	12	22
rs6548238		CC	CT	TT
Normal weight	523	356 (68)	148 (28)	19 (4)	18			0.461
Obese	500	378 (76)	115 (23)	7 (1)	13	1.450 (1.137-1.850)	0.002	0.586
rs7561317		GG	GA	AA
Normal weight	523	348 (67)	156 (30)	19 (4)	19		0.001	0.770
Obese	499	375 (75)	117 (23)	7 (1)	13	1.507 (1.184-1.918)		0.530

Data are number of subjects in each group and number of subjects for each genotype (% in each group). Minor allele frequency (MAF) for each group is given as percentage. Odds ratio (OR) with a 95% confidence interval (CI) was calculated assuming an additive model. Association with obesity was determined comparing subjects with normal weight and with obesity. P indicates p-values adjusted for sex. HWE indicates p-values for deviation from Hardy-Weinberg Equilibrium.

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