Figure 1From: The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children Schematic image of the human TMEM18 protein's features. TMEM18 has three transmembrane α-helices and the N-terminal and second loop probably face the inside of the nucleus, whereas the first loop and the C-terminal are oriented towards the cytoplasm, according to predictions by Phobius. The N-terminal contains five predicted O-β-GlcNAc glycosylation sites (red pentagons) and the second loop contains one phosphorylation site (blue star). Also, one of the glycosylation sites (*) is potentially targeted by phosphorylation. The C-terminal is annotated to contain a Coiled-coiled domain and an NLS-motif. The protein is highly conserved: blue boxes represents well conserved motifs, capital letters represent amino acids that are completely conserved in all investigated organisms and lower cases represent those conserved in 90%. Circles represent single conserved residues. The circles and amino acid letters are colored according to Zappo color scheme in Jalview. All numbers represent amino acid positions, starting at the N-terminal.Back to article page