Schematic image of the human TMEM18 protein's features. TMEM18 has three transmembrane α-helices and the N-terminal and second loop probably face the inside of the nucleus, whereas the first loop and the C-terminal are oriented towards the cytoplasm, according to predictions by Phobius. The N-terminal contains five predicted O-β-GlcNAc glycosylation sites (red pentagons) and the second loop contains one phosphorylation site (blue star). Also, one of the glycosylation sites (*) is potentially targeted by phosphorylation. The C-terminal is annotated to contain a Coiled-coiled domain and an NLS-motif. The protein is highly conserved: blue boxes represents well conserved motifs, capital letters represent amino acids that are completely conserved in all investigated organisms and lower cases represent those conserved in 90%. Circles represent single conserved residues. The circles and amino acid letters are colored according to Zappo color scheme in Jalview. All numbers represent amino acid positions, starting at the N-terminal.