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Table 1 General characteristics of study subjects

From: FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

 

European-American (EA)

African-American (AA)

Ethnicity P

(a/b)

Gender P

(a/b)

 

male

female

male

female

  
 

N

mean (SD)

N

mean (SD)

N

mean (SD)

N

mean (SD)

  

Age, years

475

17.4(3.4)

478

17.8(3.4)

457

15.2(4.4)

568

15.8(4.5)

0.52

0.19

Anthropometry and adiposity

Height (cm)

475

173.4(9.0)

478

162.6(6.9)

457

165.2(16.0)

568

158.4(10.8)

0.67

< 0.001

Weight(kg)

475

69.9(18.2)

478

60.9(15.6)

457

63.8(22.3)

568

62.6(21.1)

< 0.001**

< 0.001

BMI(kg/m2)

475

23.1(5.1)

477

22.8(4.9)

457

22.8(5.4)

566

24.5(6.6)

< 0.001**

< 0.001##

Waist circumference (cm)

474

80.4(12.9)

476

75.2(12.8)

457

74.6(13.5)

568

75.9(14.9)

0.02*

< 0.001#

Suprailiac skinfold (mm)

474

14.7(9.2)

478

18.7(9.7)

457

14.6(11.4)

568

20.7(12.0)

0.001**

< 0.001

Subscapular skinfold (mm)

474

13.2(7.8)

478

16.7(8.5)

457

14.7(9.5)

567

20.3(11.1)

< 0.001**

< 0.001

Triceps skinfold (mm)

475

13.1(7.1)

477

20.5(7.4)

457

13.6(8.3)

568

21.6(9.7)

0.74

< 0.001

Sum of skinfolds (mm)

475

41.0(22.8)

477

55.9(24.0)

457

42.9(28.1)

567

62.7(31.3)

0.001**

< 0.001

%BF

132

18.7(7.8)

144

29.4(7.1)

227

20.9(10.0)

265

29.5(8.5)

0.34

< 0.001

VAT(cm3)

64

95.8(56.2)

72

111.9(55.6)

70

67.0(49.6)

188

100.8(72.6)

< 0.001*

< 0.001

SAAT (cm3)

64

622.9(556.1)

72

903.4(517.2)

70

613.1(671.8)

187

1027.3(807.7)

0.05**

< 0.001

Insulin resistance

Fasting glucose (mmol/L)

164

5.3(0.5)

175

5.0(0.5)

192

5.3(0.6)

284

5.0(0.5)

0.35/0.86

< 0.001/< 0.001

Fasting insulin (pmol/L)

163

100.8(57.2)

169

94.2(58.0)

186

102.6(55.6)

282

131.9(76.4)

< 0.001**/< 0.001**

< 0.001##/< 0.001##

HOMA2-%B

160

130.3(48.4)

169

137.4(50.0)

186

134.3(51.2)

281

174.3(64.2)

< 0.001**/< 0.001**

< 0.001##/< 0.001##

HOMA2-IR

160

1.9(1.0)

169

1.7(1.0)

186

1.9(1.0)

281

2.4(1.3)

< 0.001**/< 0.001**

< 0.001##/< 0.001##

Environmental variables

EI(Kilojoules/d)

134

9627.9

(2373.8)

146

7292.2

(2214.1)

233

8109.3

(2809.8)

268

6939.0

(2356.7)

0.006*/0.005*

< 0.001/< 0.001

%CARBO

134

53.4(6.3)

146

55.8(6.2)

233

51.0(7.2)

269

53.5(6.9)

0.001/0.004

< 0.001/< 0.001

%PRO

134

14.4(2.8)

146

13.6(2.7)

233

14.4(3.0)

269

13.3(2.8)

0.39/0.15

< 0.001/< 0.001

%FAT

134

32.8(4.8)

146

32.0(5.2)

234

35.2(5.8)

268

34.1(5.1)

< 0.001/< 0.001

0.009/0.008

VPA (hours/d)

134

0.8(0.7)

146

0.4(0.5)

213

0.7(0.7)

257

0.3(0.5)

0.28/0.29

< 0.001/< 0.001

  1. BMI = body mass index; SD = standard deviation; %BF = percentage of body fat; VAT = visceral adipose tissue; SAAT = subcutaneous abdominal adipose tissue; HOMA2-%B = homeostasis model assessment 2 beta-cell function; HOMA2-IR = homeostasis model assessment 2 insulin resistance; EI = energy intake; %CARBO= percentage of energy from carbohydrates; %PRO= percentage of energy from protein; %FAT= percentage of energy from fat; VPA = vigorous physical activity.
  2. N: number of subjects with phenotype and genotype data;
  3. a: adjusted for age and cohort identifier; b: adjusted for age, cohort identifier and BMI
  4. *significant only in males, **significant only in females, #significant only in EAs, ##significant only in AAs.