Table 1 Single-locus SNP effects for TC with genome control (GC) adjusted P < 7.2 × 10^-8.

rs4970834

1

109814880

CELSR2 ^a (intron 28)

Non-HDL-C [5–7]

0.18

1.10E-08

1.75E-09

0.146 ± 0.023

TC [8]

rs599839

1

109822166

10 bases downstream

LDL-C [6, 7, 9, 10]

0.22

8.72E-14

2.46E-14

0.174 ± 0.021

PSRC1 ^a

Non-HDL-C [5]

rs4245791

2

44074431

ABCG8 (intron 3)

0.32

1.82E-07

3.33E-08

-0.127 ± 0.021

rs6730157

2

135907088

RAB3GAP1 (intron 17)

LDL-C: P = 0.018 [2]^b

0.45

8.51E-08

2.16E-08

0.113 ± 0.019

rs12465802

2

136381348

R3HDM1 (intron 7)

LDL-C: P = 0.022 [2]^b

0.44

2.63E-08

7.98E-09

0.117 ± 0.019

rs4954280

2

136420690

R3HDM1 (intron18)

LDL-C: P = 0.007 [2]^b

0.33

1.49E-07

5.87E-08

0.114 ± 0.02

rs2322660

2

136557319

LCT (intron 12)

LDL-C: P = 0.055 [2]^b

0.35

2.42E-08

7.08E-09

-0.120 ± 0.019

TC: P = 0.003-0.005 [17]

LDL-C: P = 0.002-0.0005 [17]

rs309180

2

136614255

MCM6 (intron 11)

LDL-C: P = 0.057 [2]^b

0.36

2.43E-08

8.39E-09

-0.119 ± 0.019

rs632632

2

136638216

4.2 kb upstream MCM6

LDL-C: P = 0.216 [2]^b

0.36

2.50E-08

1.03E-08

-0.118 ± 0.019