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Table 4 Association results for age at onset

From: Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease

  Age At Onset (cases) Age At Onset (sibship1)
Allele Carriers Non-carriers p Carriers Non-carriers p
1719A 61.7 63.2 0.52 61.8 64.4 0.16
4580A 61.8 60.4 0.61 62 61.1 0.76
7028C 61.2 62.4 0.21 61.5 62.5 0.28
8251A 61.9 59.2 0.20 62.1 59.5 0.20
9055A 62.0 59.8 0.22 62.1 60.2 0.26
10398G 60.3 62.2 0.11 60.6 62.3 0.15
10400T 57.7 61.8 0.48 60.2 62.0 0.75
12308G 60.2 62.2 0.08 59.8 62.5 0.01
13368A 61.6 63.7 0.17 61.7 63.8 0.17
13708A 61.8 62.0 0.86 62.0 61.9 0.98
16391A 61.9 58.9 0.39 62.0 58.3 0.26
H 62.2 61.5 0.49 62.4 61.6 0.41
I 59.6 61.8 0.54 59.3 62.0 0.45
J 61.4 61.8 0.80 61.7 62.0 0.89
K 59.6 62.0 0.18 60.0 62.1 0.22
M 57.7 61.8 0.48 60.2 62.0 0.75
T 63.7 61.6 0.20 63.6 61.8 0.23
U 60.4 62.0 0.26 59.4 62.3 0.03
V 60.9 61.8 0.77 61.3 62.0 0.83
W 60.2 61.8 0.67 58.9 62.0 0.38
X 65.2 61.7 0.45 67.1 61.8 0.06
Other 62.6 61.7 0.63 63.3 61.8 0.35
IJK vs. HMTUVWX 60.5 62.1 0.19 60.8 62.2 0.23
JTUK vs. HIMVWX 61.1 62.1 0.35 60.8 62.5 0.09
JTIWX vs. HKMUV 62.5 61.6 0.41 62.7 61.7 0.34
  1. 1 Since all siblings share the same mitochondrial SNP alleles and therefore haplogroups, testing for association with the mean age at onset of all affected siblings in a nuclear family is a valid and more powerful test. The number of affected siblings in a family ranged from 1 to 5.