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Table 2 Adjusted odds ratio (AOR) and 95% confidence intervals (CIs) of hepatocellular carcinoma associated with genotypic frequencies in different age groups.

From: Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma

Variable Controls n (%) Patients n (%) OR (95% CI) p value AOR (95% CI) p value
  Age > 57 years old
GSTP1 n = 149 n = 129   
II 93 (62.4%) 85 (65.9%) 1.00 1.00
IV 52 (34.9%) 40 (31.0%) 0.84 (0.5-1.3) p = 0.50 0.88 (0.5-1.4) p = 0.63
VV 4 (2.7%) 4 (3.1%) 1.09 (0.2-4.5) p = 0.90 1.06 (0.2-4.6) p = 0.93
GSTA1 n = 149 n = 129   
AA 122 (81.9%) 106 (82.2%) 1.00 1.00
AB 24 (16.1%) 22 (17.1%) 1.05 (0.5-1.9) p = 0.86 1.05 (0.5-2.0) p = 0.87
BB 3 (2.0%) 1 (0.8%) 0.38 (0.03-3.7) p = 0.40 0.47 (0.04-4.68) p = 0.52
  Age ≤ 57 years old
GSTP1 n = 237 n = 48   
II 179 (75.5%) 27 (56.3%) 1.00 1.00
IV 55 (23.2%) 18 (37.5%) 2.17 (1.1-4.2) p = 0.02 2.18 (1.1-4.3) p = 0.02
VV 3 (1.3%) 3 (6.2%) 6.63 (1.2-34.5) p = 0.02 5.64 (1.1-31.8) p = 0.04
GSTA1 n = 237 n = 48   
AA 182 (76.8%) 40 (83.3%) 1.00 1.00
AB 54 (22.8%) 8 (16.7%) 0.67 (0.2-1.5) p = 0.34 0.62 (0.2-1.4) p = 0.28
BB 1 (0.4%) 0 (0%) - p = 0.99 - p = 0.99
  1. The odds ratios (ORs) with their 95% CIs were estimated by logistic regression models.
  2. The adjusted odds ratios (AORs) with their 95% CIs were estimated by multiple logistic regression models, after controlling for gender and genotypes for each estimated variable.