Table 1 Adjusted odds ratio (AOR) and 95% confidence intervals (CIs) of hepatocellular carcinoma associated with genotypic frequencies and demographic characteristics distributions.
Variable | Controls (n = 386) (%) | Patients (n = 177) (%) | OR (95% CI) p value | AOR (95% CI) p value |
|---|---|---|---|---|
GSTP1 | Â | Â | Â | Â |
II | 272 (70.5%) | 112 (63.3%) | 1.00 | 1.00 |
IV | 107 (27.7%) | 58 (32.7%) | 1.31 (0.8-1.9) p = 0.16 | 1.16 (0.7-1.7) p = 0.46 |
VV | 7 (1.8%) | 7 (4.0%) | 2.42 (0.8-7.0) p = 0.10 | 2.26 (0.7-7.1) p = 0.16 |
II | 272 (70.5%) | 112 (63.3%) | 1.00 | 1.00 |
IV or VV | 114 (29.5%) | 65 (36.7%) | 1.38 (0.9-2.0) p = 0.09 | 1.24 (0.8-1.8) p = 0.28 |
GSTA1 | Â | Â | Â | Â |
AA | 304 (78.8%) | 146 (82.5%) | 1.00 | 1.00 |
AB | 78 (20.2%) | 30 (16.9%) | 0.80 (0.5-1.2) p = 0.34 | 0.89 (0.5-1.4) p = 0.66 |
BB | 4 (1.0%) | 1 (0.6%) | 0.52 (0.05-4.7) p = 0.56 | 0.34 (0.04-3.5) p = 0.38 |
AA | 304 (78.8%) | 146 (82.5%) | 1.00 | 1.00 |
AB or BB | 82 (21.2%) | 31 (17.5%) | 0.78 (0.4-1.2) p = 0.36 | 0.85 (0.5-1.3) p = 0.52 |
GST genes | Â | Â | Â | Â |
Combination 1 | 212 (54.9%) | 92 (52.0%) | 1.00 | 1.00 |
Combination 2 | 152 (39.4%) | 75 (42.3%) | 1.13 (0.7-1.6) p = 0.51 | 1.05 (0.7-1.5) p = 0.77 |
Combination 3 | 22 (5.7%) | 10 (5.7%) | 1.04 (0.4-2.4) p = 0.81 | 1.08 (0.4-2.5) p = 0.84 |
Age (yrs) | Â | Â | Â | Â |
|  | 54.37 ± 0.77 | 63.88 ± 0.81 | p < 0.0001 |  |
Gender | Â | Â | Â | Â |
Male | 257 (66.6%) | 128 (72.3%) | 1.00 | 1.00 |
Female | 129 (33.4%) | 49 (27.7%) | 0.76 (0.5-1.1) p = 0.17 | 1.08 (0.7-1.6) p = 0.72 |
Residential area | Mid-Taiwan | Mid-Taiwan | Â | Â |
Race | Asian | Asian | Â | Â |
Ethnicity | Taiwanese | Taiwanese | Â | Â |