|
Variable
|
Controls (n = 386) (%)
|
Patients (n = 177) (%)
|
OR (95% CI) p value
|
AOR (95% CI) p value
|
|---|
|
GSTP1
| | | | |
|---|
|
II
|
272 (70.5%)
|
112 (63.3%)
|
1.00
|
1.00
|
|
IV
|
107 (27.7%)
|
58 (32.7%)
|
1.31 (0.8-1.9) p = 0.16
|
1.16 (0.7-1.7) p = 0.46
|
|
VV
|
7 (1.8%)
|
7 (4.0%)
|
2.42 (0.8-7.0) p = 0.10
|
2.26 (0.7-7.1) p = 0.16
|
|
II
|
272 (70.5%)
|
112 (63.3%)
|
1.00
|
1.00
|
|
IV or VV
|
114 (29.5%)
|
65 (36.7%)
|
1.38 (0.9-2.0) p = 0.09
|
1.24 (0.8-1.8) p = 0.28
|
|
GSTA1
| | | | |
|
AA
|
304 (78.8%)
|
146 (82.5%)
|
1.00
|
1.00
|
|
AB
|
78 (20.2%)
|
30 (16.9%)
|
0.80 (0.5-1.2) p = 0.34
|
0.89 (0.5-1.4) p = 0.66
|
|
BB
|
4 (1.0%)
|
1 (0.6%)
|
0.52 (0.05-4.7) p = 0.56
|
0.34 (0.04-3.5) p = 0.38
|
|
AA
|
304 (78.8%)
|
146 (82.5%)
|
1.00
|
1.00
|
|
AB or BB
|
82 (21.2%)
|
31 (17.5%)
|
0.78 (0.4-1.2) p = 0.36
|
0.85 (0.5-1.3) p = 0.52
|
|
GST genes
| | | | |
|
Combination 1
|
212 (54.9%)
|
92 (52.0%)
|
1.00
|
1.00
|
|
Combination 2
|
152 (39.4%)
|
75 (42.3%)
|
1.13 (0.7-1.6) p = 0.51
|
1.05 (0.7-1.5) p = 0.77
|
|
Combination 3
|
22 (5.7%)
|
10 (5.7%)
|
1.04 (0.4-2.4) p = 0.81
|
1.08 (0.4-2.5) p = 0.84
|
|
Age (yrs)
| | | | |
| |
54.37 ± 0.77
|
63.88 ± 0.81
|
p < 0.0001
| |
|
Gender
| | | | |
|
Male
|
257 (66.6%)
|
128 (72.3%)
|
1.00
|
1.00
|
|
Female
|
129 (33.4%)
|
49 (27.7%)
|
0.76 (0.5-1.1) p = 0.17
|
1.08 (0.7-1.6) p = 0.72
|
|
Residential area
|
Mid-Taiwan
|
Mid-Taiwan
| | |
|
Race
|
Asian
|
Asian
| | |
|
Ethnicity
|
Taiwanese
|
Taiwanese
| | |
- The odds ratios (ORs) with their 95% CIs were estimated by logistic regression models.
- The adjusted odds ratios (AORs) with their 95% CIs were estimated by multiple logistic regression models, after controlling for age, gender and genotypes for each estimated variable.
- Mann-Whitney U test or Fisher's exact test was used between healthy controls and HCC patients.
- Combination 1: Individuals with Ile/Ile of GSTP1 and *A/*A of GSTA.
- Combination 2: Individuals with either genotype Ile/Val or Val/Val of GSTP1 or genotype *A/*B or *B/*B of GSTA1.
- Combination 3: Individuals with genotype Ile/Val or Val/Val of GSTP1 and genotype *A/*B or *B/*B of GSTA1.
