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Table 1 Adjusted odds ratio (AOR) and 95% confidence intervals (CIs) of hepatocellular carcinoma associated with genotypic frequencies and demographic characteristics distributions.

From: Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma

Variable Controls (n = 386) (%) Patients (n = 177) (%) OR (95% CI) p value AOR (95% CI) p value
GSTP1     
II 272 (70.5%) 112 (63.3%) 1.00 1.00
IV 107 (27.7%) 58 (32.7%) 1.31 (0.8-1.9) p = 0.16 1.16 (0.7-1.7) p = 0.46
VV 7 (1.8%) 7 (4.0%) 2.42 (0.8-7.0) p = 0.10 2.26 (0.7-7.1) p = 0.16
II 272 (70.5%) 112 (63.3%) 1.00 1.00
IV or VV 114 (29.5%) 65 (36.7%) 1.38 (0.9-2.0) p = 0.09 1.24 (0.8-1.8) p = 0.28
GSTA1     
AA 304 (78.8%) 146 (82.5%) 1.00 1.00
AB 78 (20.2%) 30 (16.9%) 0.80 (0.5-1.2) p = 0.34 0.89 (0.5-1.4) p = 0.66
BB 4 (1.0%) 1 (0.6%) 0.52 (0.05-4.7) p = 0.56 0.34 (0.04-3.5) p = 0.38
AA 304 (78.8%) 146 (82.5%) 1.00 1.00
AB or BB 82 (21.2%) 31 (17.5%) 0.78 (0.4-1.2) p = 0.36 0.85 (0.5-1.3) p = 0.52
GST genes     
Combination 1 212 (54.9%) 92 (52.0%) 1.00 1.00
Combination 2 152 (39.4%) 75 (42.3%) 1.13 (0.7-1.6) p = 0.51 1.05 (0.7-1.5) p = 0.77
Combination 3 22 (5.7%) 10 (5.7%) 1.04 (0.4-2.4) p = 0.81 1.08 (0.4-2.5) p = 0.84
Age (yrs)     
  54.37 ± 0.77 63.88 ± 0.81 p < 0.0001  
Gender     
Male 257 (66.6%) 128 (72.3%) 1.00 1.00
Female 129 (33.4%) 49 (27.7%) 0.76 (0.5-1.1) p = 0.17 1.08 (0.7-1.6) p = 0.72
Residential area Mid-Taiwan Mid-Taiwan   
Race Asian Asian   
Ethnicity Taiwanese Taiwanese   
  1. The odds ratios (ORs) with their 95% CIs were estimated by logistic regression models.
  2. The adjusted odds ratios (AORs) with their 95% CIs were estimated by multiple logistic regression models, after controlling for age, gender and genotypes for each estimated variable.
  3. Mann-Whitney U test or Fisher's exact test was used between healthy controls and HCC patients.
  4. Combination 1: Individuals with Ile/Ile of GSTP1 and *A/*A of GSTA.
  5. Combination 2: Individuals with either genotype Ile/Val or Val/Val of GSTP1 or genotype *A/*B or *B/*B of GSTA1.
  6. Combination 3: Individuals with genotype Ile/Val or Val/Val of GSTP1 and genotype *A/*B or *B/*B of GSTA1.