A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1 , SYT1 , and GABRR2 with serum creatinine level

Table 4 SNPs with the highest evidence of association in the region including the GABRR2 and the UBE2J1 genes (chromosome 6)^#.

Study	GENE	name	Position	Genotype (Ref. All.)	Ref. All. Freq.	N	Beta*	SE	p value**
EUROSPAN	GABRR2	rs6942204	90072687	C/T (C)	0.34	4001	0.0497	0.0213	0.0196
EUROSPAN	GABRR2	rs3777514	90077300	A/C (A)	0.20	3998	0.0855	0.0244	4.5 × 10^-4
EUROSPAN	Intergenic	rs2064831	90089661	C/T (C)	0.18	3995	0.1018	0.0257	7.2 × 10^-5
EUROSPAN	Intergenic	rs12195070	90090455	C/T (T)	0.19	3998	0.0722	0.0254	4.5 × 10^-3
EUROSPAN	UBE2J1	rs1998576	90099856	A/G (A)	0.18	3997	0.0993	0.0253	8.6 × 10^-5
EUROSPAN	UBE2J1	rs12189673	90103123	C/T (C)	0.30	3980	-0.0653	0.0213	2.2 × 10^-3
EUROSPAN	UBE2J1	rs1065657	90103732	C/T (T)	0.45	3999	0.0499	0.0197	0.0115
EUROSPAN	UBE2J1	rs7760851	90109323	A/G (G)	0.49	3980	-0.0505	0.0196	0.0100
EUROSPAN	UBE2J1	rs1062108	90132078	C/T (T)	0.42	3996	-0.0435	0.0198	0.0280
POPGEN	GABRR2	rs9362633	90058261	A/G (G)	0.05	1136	-0.2430	0.0795	2.2 × 10^-3
POPGEN	GABRR2	rs7764923	90079640	C/T (T)	0.23	1140	-0.1144	0.0387	3.1 × 10^-3
POPGEN	GABRR2	rs2236204	90081831	G/T (T)	0.17	1121	-0.1190	0.0436	6.4 × 10^-3
POPGEN	Intergenic	rs10944443	90087709	C/G (C)	0.15	1113	-0.1203	0.0469	0.0103
POPGEN	Intergenic	rs12195070	90090455	C/T (T)	0.18	1140	-0.1155	0.0430	7.2 × 10^-3
POPGEN	Intergenic	rs12195078	90090511	C/T (T)	0.15	1128	-0.1261	0.0460	6.1 × 10^-3
POPGEN	UBE2J1	rs9048	90094300	C/T (T)	0.18	1139	-0.1230	0.0417	3.1 × 10^-3
POPGEN	UBE2J1	rs9351207	90115388	C/T (T)	0.24	1131	-0.0791	0.0387	0.0412

^# association models were adjusted for age and sex; *in standard deviations; **p value: for EUROSPAN, the p value refers to the meta-analysis of the five individual GWA studies, for popgen, the p value is from the linear regression analysis (for details, see Methods).