A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1 , SYT1 , and GABRR2 with serum creatinine level

Table 3 SNPs with the highest evidence of association in the region upstream the SYT1 gene.^#

Study	name	position	Genotype (Ref. All.)	Ref. All. Freq.	n	Beta*	SE	p value**
EUROSPAN	rs11838060	77997790	G/T (T)	0.14	3163	-0.0696	0.0312	0.0258
EUROSPAN	rs10506807	78005428	C/T (C)	0.13	4000	-0.1141	0.0287	7.0 × 10^-5
EUROSPAN	rs12300068	78005502	A/G (A)	0.13	3997	-0.1158	0.0288	5.7 × 10^-5
EUROSPAN	rs7972593	78013149	C/T (T)	0.12	3989	-0.0978	0.0300	1.1 × 10^-3
EUROSPAN	rs11112829	78029267	C/T (C)	0.13	4000	-0.1135	0.0287	7.5 × 10^-5
POPGEN	rs12312807	77957336	A/G (A)	0.11	1139	0.1480	0.0539	6.1 × 10^-3
POPGEN	rs1527119	77964145	G/T (G)	0.11	1139	0.1471	0.0539	6.4 × 10^-3
POPGEN	rs1033196	77966968	C/T (T)	0.14	1128	0.1320	0.0479	5.8 × 10^-3
POPGEN	rs2950383	77973538	A/G (A)	0.37	1103	-0.1553	0.0359	2.0 × 10^-5
POPGEN	rs1356022	77974533	C/T (C)	0.14	1140	0.1300	0.0475	6.2 × 10^-3
POPGEN	rs12317960	77977824	C/T (T)	0.14	1140	0.1249	0.0474	8.5 × 10^-3
POPGEN	rs10506806	77979113	C/T (T)	0.31	1120	0.1012	0.0362	5.1 × 10^-3
POPGEN	rs11610381	77979918	C/T (C)	0.14	1134	0.1321	0.0476	5.5 × 10^-3
POPGEN	rs7971081	77980051	C/T (C)	0.14	1140	0.1296	0.0474	6.3 × 10^-3

^# association models were adjusted for age and sex; *in standard deviations; **p value: for EUROSPAN, the p value refers to the meta-analysis of the five individual GWA studies, for popgen, the p value is from the linear regression analysis (for details, see Methods).