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Table 2 SNPs showing the highest evidence of association in the COL22A1 gene (chromosome 8).#

From: A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2with serum creatinine level

study name position Genotype (Ref. All.) Ref. All. Freq. n Beta* SE p value**
EUROSPAN rs4075073 139808143 A/C (A) 0.37 3996 0.0671 0.0203 9.8 × 10-4
EUROSPAN rs4588898 139815390 A/G (A) 0.30 3999 0.0786 0.0212 2.1 × 10-4
EUROSPAN rs13255079 139828786 C/T (T) 0.16 4001 0.0769 0.0263 3.4 × 10-3
EUROSPAN rs9324496 139833578 C/T (T) 0.34 3995 0.0716 0.0205 4.6 × 10-4
EUROSPAN rs7824025 139839898 A/C (A) 0.07 3998 0.0762 0.0374 0.0414
EUROSPAN rs2873682 139840693 A/G (A) 0.30 2610 0.0915 0.0264 5.2 × 10-4
EUROSPAN rs11166844 139848062 C/T (C) 0.39 3993 0.0485 0.0202 0.0166
EUROSPAN rs1574172 139941802 A/G (A) 0.14 3998 -0.0713 0.0284 0.0122
EUROSPAN rs4736078 139944298 C/T (C) 0.22 3996 -0.0503 0.0242 0.0373
EUROSPAN rs6986041 139988449 C/T (C) 0.35 3936 -0.0583 0.0207 4.8 × 10-3
POPGEN rs4282617 139795530 C/G (C) 0.25 1139 -0.0822 0.0398 0.0391
POPGEN rs10092896 139856976 C/T (C) 0.27 1139 -0.1123 0.0380 3.1 × 10-3
POPGEN rs2318334 139859320 C/T (C) 0.25 1140 -0.1115 0.0390 4.2 × 10-3
POPGEN rs1574370 139866164 A/G (A) 0.24 1126 -0.0992 0.0402 0.0137
POPGEN rs6991720 139871695 C/G (G) 0.25 1139 -0.1074 0.0391 6.1 × 10-3
POPGEN rs7837787 139875897 A/G (G) 0.25 1140 -0.1106 0.0391 4.7 × 10-3
POPGEN rs12155960 139886087 A/G (G) 0.26 1134 -0.1152 0.0388 3.0 × 10-3
POPGEN rs11779129 139888085 A/C (A) 0.25 1140 -0.0992 0.0388 0.0105
POPGEN rs16893541 139890024 C/G (C) 0.27 1124 -0.1089 0.0390 5.2 × 10-3
POPGEN rs12549194 139896019 A/C (C) 0.26 1137 -0.0830 0.0388 0.0327
POPGEN rs10093925 139904787 C/T (T) 0.36 1124 -0.0687 0.0347 0.0478
POPGEN rs6577953 139914021 C/G (C) 0.40 1139 -0.1032 0.0336 2.1 × 10-3
POPGEN rs6993839 139914702 A/G (G) 0.39 1131 -0.1029 0.0342 2.6 × 10-3
POPGEN rs9650564 139918011 C/T (C) 0.41 1139 -0.1017 0.0338 2.6 × 10-3
POPGEN rs9650565 139918089 C/T (C) 0.41 1133 -0.0944 0.0339 5.3 × 10-3
POPGEN rs7014497 139923457 C/T (C) 0.39 1133 -0.0892 0.0341 8.9 × 10-3
POPGEN rs9650566 139923872 A/G (G) 0.46 1139 -0.1054 0.0332 1.5 × 10-3
POPGEN rs17740495 139941879 C/T (C) 0.08 1136 0.1393 0.0603 0.0209
POPGEN rs16893545 139948143 A/C (C) 0.18 1140 0.0953 0.0440 0.0304
KORCULA rs4076439 139690550 A/G (G) 0.25 895 0.0907 0.0393 0.0209
KORCULA rs4341165 139692067 C/T (C) 0.25 895 0.0907 0.0393 0.0209
KORCULA rs4909439 139727929 C/T (C) 0.17 895 0.1080 0.0518 0.0371
KORCULA rs3923549 139732799 C/T (T) 0.10 895 0.1513 0.0704 0.0316
KORCULA rs4073446 139735056 C/T (T) 0.11 895 0.1555 0.0658 0.0182
KORCULA rs7839680 139762863 A/G (A) 0.18 895 0.0950 0.0472 0.0440
KORCULA rs4909444 139770391 G/T (T) 0.38 895 0.0623 0.0289 0.0309
KORCULA rs4074052 139785008 C/T (T) 0.46 894 -0.0504 0.0248 0.0419
KORCULA rs10112806 139806115 A/C (C) 0.41 895 -0.0589 0.0280 0.0357
KORCULA rs1320279 139899978 C/T (C) 0.11 895 -0.1823 0.0662 5.9 × 10-3
KORCULA rs2318345 139970360 C/T (C) 0.09 894 0.1755 0.0720 0.0147
  1. # association models were adjusted for age and sex; *in standard deviations; **p value: for EUROSPAN, the p value refers to the meta-analysis of the five individual GWA studies, for popgen and Korcula, the p value is from the linear regression analysis (for details, see Methods).