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Table 1 Characteristics of studies and study participants.

From: A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2with serum creatinine level

 

EUROSPAN

REPLICATION STUDIES

Study name

ERF

MICROS

NSPHS

ORCADES

VIS

popgen

Korcula

Nationality

The Netherlands

Italy

Sweden

UK

Croatia

Germany

Croatia

Population type

isolated

isolated

isolated

isolated

isolated

general

isolated

Genotyping platform

Illumina 318 K

Illumina 318 K

Illumina 318 K

Illumina 318 K

Illumina 318 K

Affymetrix 1000 K

Illumina 370 K

Sample size*

775

1086

653

718

774

1140

895

Females: n (%)

472 (61%)

615 (57%)

345 (53%)

385 (54%)

454 (59%)

534 (47%)

572 (64%)

Age: mean (sd)

53 (15)

45 (16)

47 (21)

54 (16)

57 (15)

54 (15)

56 (14)

Diabetes: n (%)

36 (4.9%)

39 (3.6%)

44 (6.7%)

21 (3.0%)

72 (9.4%)

18 (1.6%)

93 (10.3%)

AHT # : n (%)

190 (24.5%)

85 (7.8%)

124 (19.0%)

152 (21.2%)

192 (25.2%)

Not available

197 (22.0%)

S CR mg/dl: mean (sd)

       

Males

1.01 (0.20)

0.96 (0.14)

0.94 (0.20)

0.97 (0.15)

1.01 (0.31)

0.93 (0.15)

0.92 (0.15)

Females

0.85 (0.21)

0.78 (0.12)

0.75 (0.14)

0.77 (0.19)

0.79 (0.27)

0.74 (0.12)

0.75 (0.12)

eGFR † ml/min/1.73 m2

       

Males

81.1 (19.0)

87.8 (15.1)

92.2 (22.1)

84.3 (16.0)

82.0 (19.4)

88.0 (17.5)

77.1 (14.9)

Females

75.8 (20.5)

83.4 (16.8)

88.7 (19.2)

81.5 (18.5)

81.0 (19.8)

85.5 (17.2)

72.4 (14.1)

  1. * Number of individuals with available creatinine, sex, and age information.
  2. # AHT: Anti-hypertensive treatment
  3. † Estimated using the updated abbreviated MDRD study equation [58]