Manhattan plot of -log
(p values) from the meta-analysis of five GWA studies. GWA results were combined across all studies by fixed-effects meta-analysis using inverse variance weighting. Square dots indicate SNPs satisfying criteria for selection of candidate regions. SNPs within replicated regions are colored in dark red and SNPs within non-replicated regions in pink. The genomic control factor of λ = 1.004, assessed by the quantile-quantile plot in the upper-right panel, indicates that cryptic relatedness and population structure have been modeled appropriately.