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Table 2 Genotype frequency distribution and association with stroke outcome at three months for MMP-2 SNPs.

From: Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke

   Whole sample* Ischemic subset
   Genotype frequency    Genotype frequency   
SNP Genotype Good recovery, n (%) Poor recovery, n (%) OR [95%CI] P Good recovery, n (%) Poor recovery, n (%) OR [95%CI] P
rs243866          
  G/G 142 (67.6) 117 (57.9) 1.67 [1.10-2.52] 0.0143 125 (67.6) 83 (56.8) 1.78 [1.13-2.80] 0.0128
  A/G 66 (31.4) 76 (37.6)    59 (31.9) 55 (37.7)   
  A/A 2 (1.0) 9 (4.5)    1 (0.5) 8 (5.5)   
rs243865          
  C/C 141 (67.8) 117 (57.9) 1.65 [1.09-2.50] 0.0162 124 (67.8) 83 (56.8) 1.76 [1.12-2.78] 0.0143
  C/T 65 (31.2) 76 (37.6)    58 (31.7) 55 (37.7)   
  T/T 2 (1.0) 9 (4.5)    1 (0.5) 8 (5.5)   
rs857403          
  A/A 124 (59.3) 138 (68.3) 0.71 [0.48-1.06] 0.0909 105 (57.1) 103 (70.5) 0.62 [0.40-0.97] 0.0349
  T/A 75 (35.9) 56 (27.7)    70 (38) 37 (25.3)   
  T/T 10 (4.8) 8 (4.0)    9 (4.9) 6 (4.1)   
rs1477017          
  A/A 100 (47.6) 81 (40.1) 1.42 [1.01-2.00] 0.0415 86 (46.5) 55 (37.7) 1.51 [1.04-2.20] 0.0306
  G/A 91 (43.3) 98 (48.5)    82 (44.3) 72 (49.3)   
  G/G 19 (9.0) 23 (11.4)    17 (9.2) 19 (13)   
rs17301608          
  C/C 94 (45.0) 75 (37.3) 1.40 [1.00-1.95] 0.0510 80 (43.5) 50 (34.5) 1.47 [1.01-2.12] 0.0412
  C/T 94 (45.0) 100 (49.8)    85 (46.2) 73 (50.3)   
  T/T 21 (10.0) 26 (12.9)    19 (10.3) 22 (15.2)   
rs1053605          
  C/C 188 (89.5) 170 (84.2) 2.02 [1.09-3.75] 0.0227 166 (89.7) 127 (87.0) 1.82 [0.93-3.58] 0.0817
  C/T 22 (10.5) 28 (13.9)    19 (10.3) 16 (11.0)   
  T/T 0 (0.0) 4 (2.0)    0 (0.0) 3 (2.0)   
rs2241145          
  G/G 79 (37.8) 56 (27.9) 1.66 [1.20-2.30] 0.0021 68 (37.0) 39 (26.9) 1.67 [1.17-2.40] 0.0044
  G/C 100 (47.8) 101 (50.2)    88 (47.8) 72 (49.7)   
  C/C 30 (14.4) 44 (21.9)    28 (15.2) 34 (23.4)   
rs243849          
  C/C 131 (62.7) 143 (71.5) 0.70 [0.46-1.07] 0.0948 112 (60.9) 108 (75) 0.59 [0.36-0.96] 0.0314
  T/C 70 (33.5) 52 (26.0)    65 (35.3) 33 (22.9)   
  T/T 8 (3.8) 5 (2.5)    7 (3.8) 3 (2.1)   
rs183112          
  G/G 134 (64.1) 145 (72.9) 0.66 [0.43-1.03] 0.0669 115 (62.5) 110 (76.9) 0.54 [0.32-0.90] 0.0162
  A/G 70 (33.5) 51 (25.6)    65 (35.3) 32 (22.4)   
  A/A 5 (2.4) 3 (1.5)    4 (2.2) 1 (0.7)   
rs1992116          
  G/G 87 (41.6) 65 (32.3) 1.67 [1.20-2.31] 0.0018 76 (41.3) 48 (33.1) 1.68 [1.17-2.42] 0.0042
  A/G 97 (46.4) 94 (46.8)    86 (46.7) 67 (46.2)   
  A/A 25 (12.0) 42 (20.9)    22 (12.0) 30 (20.7)   
  1. 95%CI - 95% Confidence Interval.
  2. *OR [95%CI] and P for the log-additive genetic model after adjustment for significant covariates (history of hypertension, type of stroke, and occurrence of aphasia, paresis, consciousness disturbance and complications during hospitalization).
  3. OR [95%CI] and P for the log-additive genetic model after adjustment for significant covariates (history of hypertension, and occurrence of aphasia, paresis, consciousness disturbance and complications during hospitalization).
  4. Significant result after Bonferroni correction.
  5. Results were adjusted for significant covariates; Odds Ratio (OR)>1 indicates increased probability of poor recovery for the carriers of the minor allele; only associated SNPs are shown.