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Table 6 Associations of glucocorticoid receptor haplotype with the risks of prenatal growth deceleration and postnatal growth acceleration until 24 months of age

From: Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study

  Prenatal growth deceleration
(95% CI)
Postnatal growth acceleration
(95% CI)
Glucocorticoid receptor haplotype (copies) Growth deceleration
(>-0.67 SDS)
Growth acceleration
(>0.67 SDS)
Haplotype 1   
   0 1.09 (0.84, 1.42) 1.07 (0.78, 1.48)
   1 1.16 (0.95, 1.41) 1.11 (0.87, 1.42)
   2 Reference Reference
Haplotype 2   
   0 Reference Reference
   1 0.88 (0.73, 1.07) 0.99 (0.79, 1.26)
   2 1.03 (0.68, 1.55) 1.20 (0.73, 1.97)
Haplotype 3   
   0 Reference Reference
   1 1.17 (0.95, 1.43) 1.05 (0.82, 1.35)
   2 0.90 (0.45, 1.84) 0.42 (0.13, 1.39)
Haplotype 4   
   0 Reference Reference
   1 0.88 (0.71, 1.09) 0.97 (0.74, 1.25)
   2 0.93 (0.47, 1.84) 0.80 (0.27, 2.39)
Haplotype 5   
   0 Reference Reference
   1 or 2 0.96 (0.69, 1.34) 0.96 (0.65, 1.42)
Haplotype 6   
   0 Reference Reference
   1 or 2 1.26 (0.86, 1.87) 1.28 (0.80, 2.07)
  1. Values are odds ratios (95% confidence interval) and reflect the difference in risk of prenatal growth deceleration and postnatal growth acceleration until 24 months of age for the different glucocorticoid haplotypes compared to the reference group (-0.67 to 0.67 SDS change in weight SDS). SDS, gestational age adjusted standard deviation score; CI, confidence interval. Models are adjusted for age at visit and gender.