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Table 5 Associations of glucocorticoid receptor haplotype with repeatedly measured head circumference from mid-pregnancy until 14 months of age

From: Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study

  Head circumference SDS change
2ndtrimester - birth
(95% CI)
Head circumference SDS change
Birth - 14 months
(95% CI)
Head circumference SDS change
2ndtrimester - 14 months
(95% CI)
Glucocorticoid receptor haplotype (copies)    
Haplotype 1    
   0 -0.10 (-0.20, 0.01) -0.16 (-0.33, 0.01) -0.09 (-0.18, 0.01)
   1 -0.05 (-0.13, 0.03) -0.11 (-0.24, 0.02) -0.06 (-0.13, 0.01)
   2 Reference Reference Reference
Haplotype 2    
   0 Reference Reference Reference
   1 -0.07 (-0.16, 0.01) 0.01 (-0.11, 0.12) -0.05 (-0.12, 0.02)
   2 -0.12 (-0.30, 0.06) 0.08 (-0.18, 0.35) -0.02 (-0.17, 0.13)
Haplotype 3    
   0 Reference Reference Reference
   1 0.11 (0.03, 0.20)* 0.12 (-0.01, 0.25) 0.10 (0.02, 0.17)†
   2 0.11 (-0.17, 0.40) -0.12 (-0.53, 0.29) 0.08 (-0.16, 0.33)
Haplotype 4    
   0 Reference Reference Reference
   1 0.01 (-0.07, 0.10) 0.08 (-0.05, 0.21) 0.12 (-0.15, 0.40)
   2 0.18 (-0.12, 0.47) 0.19 (-0.22, 0.60) 0.17 (-0.10, 0.44)
Haplotype 5    
   0 Reference Reference Reference
   1 or 2 -0.10 (-0.33, 0.13) -0.17 (-0.38, 0.03) 0.02 (-0.10, 0.14)
Haplotype 6    
   0 Reference Reference Reference
   1 or 2 0.07 (-0.09, 0.22) 0.07 (-0.15, 0.29) 0.06 (-0.07, 0.19)
  1. Values are regression coefficients (95% confidence interval) and reflect the difference in standard deviation score of head circumference from 2nd trimester until 14 months of age for the different glucocorticoid haplotypes. SDS, gestational age adjusted standard deviation score; CI, confidence interval. Models are adjusted for age at visit and gender.