Skip to main content

Table 4 Associations of glucocorticoid receptor haplotype with repeatedly measured length from mid-pregnancy until 24 months of age

From: Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study

  Length SDS change
2ndtrimester - birth
(95% CI)
Length SDS change
Birth - 24 months
(95% CI)
Length SDS change
2ndtrimester - 24 months
(95% CI)
Glucocorticoid receptor haplotype (copies)    
Haplotype 1    
   0 0.01 (-0.09, 0.10 -0.01 (-0.13, 0.12) 0.01 (-0.09, 0.10)
   1 0.02 (-0.05, 0.09) -0.01 (-0.10, 0.09) 0.01 (-0.07, 0.08)
   2 Reference Reference Reference
Haplotype 2    
   0 Reference Reference Reference
   1 0.02 (-0.08, 0.12) 0.02 (-0.07, 0.11) -0.07 (-0.14, 0.01)
   2 0.08 (-0.08, 0.24) 0.03 (-0.19, 0.26) 0.10 (-0.06, 0.26)
Haplotype 3    
   0 Reference Reference Reference
   1 0.09 (0.02, 0.16)* 0.05 (-0.05, 0.15) 0.07 (-0.01, 0.14)
   2 0.16 (-0.08, 0.40) 0.13 (-0.24, 0.50) 0.12 (-0.15, 0.38)
Haplotype 4    
   0 Reference Reference Reference
   1 -0.03 (-0.10, 0.05) -0.07 (-0.17, 0.04) -0.02 (-0.10, 0.06)
   2 -0.23 (-0.47, 0.01) -0.02 (-0.40, 0.34) -0.15 (-0.42, 0.11)
Haplotype 5    
   0 Reference Reference Reference
   1 or 2 0.14 (0.02, 0.25)* 0.02 (-0.14, 0.19) 0.18 (0.05, 0.30)†
Haplotype 6    
   0 Reference Reference Reference
   1 or 2 -0.10 (-0.23, 0.03) -0.05 (-0.23, 0.14) -0.11 (-0.25, 0.03)
  1. Values are regression coefficients (95% confidence interval) and reflect the difference in standard deviation score of length from 2nd trimester until 24 months of age for the different glucocorticoid haplotypes. SDS, gestational age adjusted standard deviation score; CI, confidence interval. Models are adjusted for age at visit and gender.