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Table 3 Associations of glucocorticoid receptor haplotype with repeatedly measured weight from mid-pregnancy until 24 months of age

From: Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study

  Weight SDS change
2ndtrimester - birth
(95% CI)
Weight SDS change
Birth - 24 months
(95% CI)
Weight SDS change
2ndtrimester - 24 months
(95% CI)
Glucocorticoid receptor haplotype (copies)    
Haplotype 1    
   0 0.03 (-0.06, 0.12) -0.02 (-0.12, 0.08) 0.05 (-0.05, 0.15)
   1 0.02 (-0.05, 0.09) -0.03 (-0.11, 0.05) 0.03 (-0.04, 0.11)
   2 Reference Reference Reference
Haplotype 2    
   0 Reference Reference Reference
   1 -0.06 (-0.12, 0.01) -0.02 (-0.09, 0.06) -0.10 (-0.17, -0.03)*
   2 -0.01 (-0.15, 0.13) -0.01 (-0.17, 0.16) -0.02 (-0.18, 0.15)
Haplotype 3    
   0 Reference Reference Reference
   1 0.06 (-0.01, 0.14) 0.06 (-0.02, 0.14) 0.09 (0.01, 0.17)*
   2 0.02 (-0.21, 0.25) 0.02 (-0.26, 0.29) 0.14(-0.14, 0.42)
Haplotype 4    
   0 Reference Reference Reference
   1 -0.02 (-0.09, 0.05) 0.02 (-0.07, 0.10) 0.12 (-0.15, 0.40)
   2 -0.21 (-0.43, 0.02) 0.07 (-0.21, 0.36) 0.16 (-0.10, 0.44)
Haplotype 5    
   0 Reference Reference Reference
   1 or 2 -0.01 (-0.18, 0.16) -0.36 (-1.02, 0.29) -0.16 (-0.75, 0.43)
Haplotype 6    
   0 Reference Reference Reference
   1 or 2 -0.20 (-0.41, 0.01) 0.97 (-0.99, 2.93) 0.54 (0.13, 0.96)*
  1. Values are regression coefficients (95% confidence interval) and reflect the difference in standard deviation score of weight from 2nd trimester until 24 months of age for the different glucocorticoid haplotypes. SDS, gestational age adjusted standard deviation score; CI, confidence interval. Models are adjusted for age at visit and gender.