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Table 2 Polymorphisms Tested that had Previously Been Reported as Associated with Tuberculosis

From: Polymorphisms in IL-1β, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis

Gene SNP rs number References
NRAMP1(Slc11a1) 5'(GT)n microsatellite ------------ [1, 22–26]
  INT4 (469+14G/C) rs3731865 [1, 26]
  D543N rs17235409 [1, 27, 24, 28, 26]
  3'UTR (1729+55del4) rs17235416 [1, 27, 28, 26]
  274C/T rs2276631 [29]
SP110 sp110 intron 6 rs2114592 [30]
  sp110 exon 11 rs3948464 [30]
IL-12/23/IFN-γ Pathway +874A/T rs2430561 [31–35]
  -1616G rs2069705 [36]
  +3234T rs2069718 [36]
  IFNGR1 -56C/T rs2234711 [36]
IL-1 and IL-1 RA IL-1α -899 C/T rs1800587 [37]
  IL-1β +3953 C/T rs1143634 [38]
  IL-1β -511 C/T rs16944 [39]
  IL-1RA microsatellite ------------- [40]
IL-10 -1082 G/A rs1800896 [41, 34, 42]
  -592 A/C rs1800872 [43]
MBL Codon 52 C/T (allele D) rs5030737 [44]
  Codon 54 A/G (allele B) rs1800450 [44]
  Codon 57 A/G (allele C) rs1800451 [44]
VDR Taq1 C/T rs731236 [11, 2, 45]
  Fok1 A/G rs10735810 [11, 28]
  Bsm1 rs154410 [45]
MCP-1 -2518A/G rs1024611 [46]
TIRAP C558T rs7932766 [47]
TLR2 GT repeat intII microsatellite -------------- [18]
  Arg753Gln rs5743708 [48]
  Arg677Trp rs6265786 [49]
P2X7 -762T/C rs2393799 [50]
  1513A/C rs3751143 [51]
  1. Polymorphisms were reported in the literature prior to November 15, 2006. There were 27 single nucleotide polymorphisms (SNPs) and three microsatellites. The status of each polymorphism tested in this study is provided.
  2. Abbreviations (names of genes):
  3. NRAMP-1 natural resistance-associated macrophage protein-1
  4. SP110 speckled 110, nuclear hormone receptor co-activator
  5. IL-12/23 interleukin-12/23
  6. IFN-γ interferon-gamma
  7. IFNGR1 interferon-gamma receptor 1
  8. VDR vitamin D receptor
  9. IL-1 interleukin-1
  10. MCP-1 monocyte chemoattractant protein-1
  11. IL-1 RA interleukin-1 receptor antagonist
  12. TIRAP toll-interleukin 1 receptor adapter protein
  13. IL-10 interleukin-10
  14. TLR2 toll-like receptor 2
  15. MBL mannose binding lectin
  16. P2X7 purinoreceptor
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BMC Medical Genetics

ISSN: 1471-2350

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