Polymorphisms in IL-1β, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis

Table 2 Polymorphisms Tested that had Previously Been Reported as Associated with Tuberculosis

Gene	SNP	rs number	References
NRAMP1(Slc11a1)	5'(GT)_n microsatellite	------------	[1, 22–26]
	INT4 (469+14G/C)	rs3731865	[1, 26]
	D543N	rs17235409	[1, 27, 24, 28, 26]
	3'UTR (1729+55del4)	rs17235416	[1, 27, 28, 26]
	274C/T	rs2276631	[29]
SP110	sp110 intron 6	rs2114592	[30]
	sp110 exon 11	rs3948464	[30]
IL-12/23/IFN-γ Pathway	+874A/T	rs2430561	[31–35]
	-1616G	rs2069705	[36]
	+3234T	rs2069718	[36]
	IFNGR1 -56C/T	rs2234711	[36]
IL-1 and IL-1 RA	IL-1α -899 C/T	rs1800587	[37]
	IL-1β +3953 C/T	rs1143634	[38]
	IL-1β -511 C/T	rs16944	[39]
	IL-1RA microsatellite	-------------	[40]
IL-10	-1082 G/A	rs1800896	[41, 34, 42]
	-592 A/C	rs1800872	[43]
MBL	Codon 52 C/T (allele D)	rs5030737	[44]
	Codon 54 A/G (allele B)	rs1800450	[44]
	Codon 57 A/G (allele C)	rs1800451	[44]
VDR	Taq1 C/T	rs731236	[11, 2, 45]
	Fok1 A/G	rs10735810	[11, 28]
	Bsm1	rs154410	[45]
MCP-1	-2518A/G	rs1024611	[46]
TIRAP	C558T	rs7932766	[47]
TLR2	GT repeat intII microsatellite	--------------	[18]
	Arg753Gln	rs5743708	[48]
	Arg677Trp	rs6265786	[49]
P2X7	-762T/C	rs2393799	[50]
	1513A/C	rs3751143	[51]

Polymorphisms were reported in the literature prior to November 15, 2006. There were 27 single nucleotide polymorphisms (SNPs) and three microsatellites. The status of each polymorphism tested in this study is provided.
Abbreviations (names of genes):
NRAMP-1 natural resistance-associated macrophage protein-1
SP110 speckled 110, nuclear hormone receptor co-activator
IL-12/23 interleukin-12/23
IFN-γ interferon-gamma
IFNGR1 interferon-gamma receptor 1
VDR vitamin D receptor
IL-1 interleukin-1
MCP-1 monocyte chemoattractant protein-1
IL-1 RA interleukin-1 receptor antagonist
TIRAP toll-interleukin 1 receptor adapter protein
IL-10 interleukin-10
TLR2 toll-like receptor 2
MBL mannose binding lectin
P2X7 purinoreceptor

ISSN: 1471-2350