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Table 2 Association of DOK5 SNPs with type 2 diabetes in North Indian population

From: Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population

SNP

Entire Sample set

Normal-weight subjects

Over-weight/obese subjects

 

Case: Control

(1019: 1006)

OR (95%CI)

P value

ORadj(95%CI)

P adj value

Case: Control

(295: 436)

OR (95%CI)

P value

ORadj(95%CI)

P adj value

Case: Control

(691: 561)

OR (95%CI)

P value

ORadj(95%CI)

P adj value

rs6023357 (A/C)

814: 822

196: 165

7: 16

1.06

(0.86-1.30)

0.597

1.10

(0.90-1.36)

0.355

236: 351

56: 77

1: 6

0.96

(0.68-1.36)

0.825

0.95

(0.65-1.39)

0.799

548: 465

137: 87

6: 9

1.17

(0.90-1.52)

0.246

1.16

(0.89-1.50)

0.276

rs6023367 (G/A)

794: 792

218: 202

7: 11

1.03

(0.84-1.25)

0.810

1.06

(0.86-1.29)

0.606

223: 341

70: 92

2: 3

1.14

(0.82-1.60)

0.432

1.19

(0.83-1.71)

0.335

548: 446

138: 107

5: 8

0.97

(0.75-1.26)

0.838

0.97

(0.75-1.26)

0.829

rs6068915 (C/T)

772: 759

229: 217

17: 28

0.95

(0.79-1.13)

0.533

0.95

(0.79-1.13)

0.562

226: 324

63: 98

6: 14

0.87

(0.65-1.17)

0.361

0.91

(0.66-1.24)

0.538

525: 430

154: 116

11: 14

0.99

(0.79-1.25)

0.940

0.97

(0.77-1.23)

0.830

rs6064099 (G/C)

589: 576

366: 369

64: 60

1.00

(0.86-1.15)

0.948

1.00

(0.86-1.16)

0.990

185: 239

95: 161

15: 36

0.75

(0.59-0.95)

0.019

0.78

(0.60-1.01)

0.063

385: 331

259: 207

47: 23

1.18

(0.98-1.42)

0.080

1.18

(0.98-1.43)

0.080

rs873079 (G/A)

607: 591

356: 364

56: 50

0.99

(0.86-1.15)

0.927

0.99

(0.85-1.15)

0.861

191: 248

91: 162

13: 26

0.76

(0.59-0.98)

0.036

0.78

(0.59-1.02)

0.065

397: 337

253: 201

41: 23

1.14

(0.94-1.37)

0.186

1.14

(0.94-1.38)

0.176

DK176673 (T/A)

847: 807

107: 110

6: 1

1.02

(0.78-1.33)

0.900

1.04

(0.79-1.37)

0.791

236: 359

38: 43

5: 1

1.55

(1.03-2.34)

0.037

1.58

(1.01-2.46)

0.043

584: 441

63: 66

1: 0

0.75

(0.52-1.07)

0.116

0.76

(0.53-1.09)

0.132

  1. Data are presented as genotype counts. OR (95% CI) stands for odds ratio with 95% confidence interval assuming additive model. ORadj and P adj were calculated by logistic regression analysis after adjustments for age, sex and BMI.