Table 2 Epidermal growth factor receptor and K-ras mutations.
From: Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer
| Â | Site | Wild type | Type of point mutation | Number of mutations (%) | Amino acid | Heterozygous/homozygous |
|---|---|---|---|---|---|---|
EGFRa [SME1] | Exon 18 | AAG | 2183A>G | 1 (33.3) | Gln849Leu | Heterozygous |
| Â | Exon 21 | CAG | 2546A>T | 1 (33.3) | Lys728Arg | Heterozygous |
| Â | Exon 21 | GCA | 2611G>A | 1 (33.3) | Ala871Thr | Heterozygous |
K-ras | Codon 12 | GGT | 35G>A | 16 (47.1) | Gly12Asp | Heterozygous |
| Â | Codon 12 | GGT | 34G>T | 6 (17.6) | Gly12Cys | Heterozygous |
| Â | Codon 12 | GGT | 34G>A | 3 (8.8) | Gly12Ser | Heterozygous |
| Â | Codon 12 | GGT | 34G>A | 1 (2.9) | Gly12Ser | Homozygous |
| Â | Codon 12 | GGT | 34G>T | 1 (2.9) | Gly12Cys | Homozygous |
| Â | Codon 12 | GGT | 35G>C | 1 (2.9) | Gly12Ala | Heterozygous |
| Â | Codon 12 | GGT | 35G>A | 1 (2.9) | Gly12Asp | Homozygous |
| Â | Codon 12 | GGT | 35G>T | 1 (2.9) | Gly12Val | Heterozygous |
| Â | Codon 13 | GGC | 38G>A | 1 (2.9) | Gly13Asp | Heterozygous |
| Â | Codon 45 | GTA | 133G>A | 1 (2.9) | Val45Ile | Homozygous |
| Â | Codon 69 | GAC | 205G>A | 1 (2.9) | Asp69Asn | Homozygous |
| Â | Codon 80 | TGT | 239G>A | 1 (2.9) | Cys80Tyr | Heterozygous |