Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status

Table 5 Genotype frequencies of IL-1RN VNTR comparison of 53 professional athletes and 152 non-professional athletes and 458 non-athlete controls.

	Professional Athletes (n = 53)	Non-professional Athletes (n = 152)	OR^a (95% CI)	P-value^a	OR^b (95% CI)	P-value^b	OR^c (95% CI)	P-value^c
IL-1RN VNTR genotype				0.084		< 0.001		0.047
1/1	19 (35.8%)	71 (46.7%)	0.64 (0.33-1.22)	0.200	0.40 (0.22-0.72)	0.002	0.62 (0.43-0.90)	0.012
1/2	28 (52.8%)	56 (36.8%)	1.92 (1.02-3.61)	0.042	3.12 (1.75-5.56)	< 0.001	1.62 (1.10-2.40)	0.014
1/3	0	3 (2.0%)	0.98 (0.96-1.00)	0.570	0.96 (0.94-0.98)	0.250	0.44 (0.13-1.51)	0.225
2/2	3 (5.7%)	19 (12.5%)	0.42 (0.12-1.48)	0.205	0.59 (0.18-1.99)	0.607	1.41 (0.80-2.52)	0.236
2/3	2 (3.8%)	2 (1.3%)	2.94 (0.40-21.4)	0.275	5.95 (0.97-36.4)	0.086	2.02 (0.33-12.2)	0.603
1/2 and 2/2 and 2/3 and 2/4	33 (62.3%)	77 (50.7%)	1.61 (0.85-3.05)	0.145	2.84 (1.58-5.12)	< 0.001	1.77 (1.22-2.57)	0.002
1/3 and 2/3 and 3/3	2 (5.2%)	6 (3.7%)	0.95 (0.19-4.88)	1.000	0.71 (0.16-3.09)	1.000	0.74 (0.30-1.85)	0.523
IL-1RN VNTR allele				0.498		0.019		0.023
Allele 1	67 (63.2%)	201(66.1%)
Allele 2	36 (34.0%)	96 (31.6%)
Allele 3	2 (1.9%)	7 (2.3%)

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