Table 3 Allele and genotype frequencies for the four polymorphisms of the LEPR gene
Allelea | Genotype | ||||||||
|---|---|---|---|---|---|---|---|---|---|
n | 1b | 2b | χ2 (P value) | Odds ratio (95% CI) | 11b | 12b | 22b | χ2 (P value) | |
LEPR c.326A>G | |||||||||
Control | 83 | 38 (23%) | 128 (77%) | 0.6 (p = 0.437) | 0.81 (0.49-1.36) | 9 (11%) | 20 (24%) | 54 (65%) | 4.83 (p = 0.089) |
HELLP | 75 | 40 (17%) | 110 (73%) | 5 (7%) | 30 (40%) | 40 (53%) | |||
LEPR c.668A>G | |||||||||
Control | 83 | 69 (42%) | 97 (58%) | 0.3 (p = 0.578) | 0.88 (0.56-1.38) | 18 (22%) | 33 (40%) | 32(38%) | 0.48 (p = 0.785) |
HELLP | 75 | 67 (45%) | 83 (55%) | 17 (23%) | 33 (44%) | 25 (33%) | |||
LEPR c.1968G>C | |||||||||
Control | 83 | 140(84%) | 26 (16%) | 1.01 (p = 0.313) | 0.74 (0.41-1.32) | 59 (71%) | 22 (27%) | 2 (2%) | 1.01 (p = 0.602) |
HELLP | 75 | 120 (80%) | 30 (20%) | 48(64%) | 24 (32%) | 3 (4%) | |||
LEPR c.3024A>G | |||||||||
Control | 83 | 113 (68%) | 53 (32%) | 1.28 (p = 0.258) | 0.76 (0.48-1.2) | 10 (12%) | 33 (40%) | 40 (48%) | 3.66 (p = 0.16) |
HELLP | 75 | 93 (62%) | 57 (38%) | 8 (11%) | 41 (54%) | 26 (35%) | |||