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Table 2 Calculated odds ratios from the prevalence of clinical and asymptomatic malaria in AS, SS individuals in Massalit and Hausa:

From: Loss of balancing selection in the βS globin locus

 

HbA

HbS

HbS Allele Frequency

Odds Ratio (95%Cl)

Relative Risk (95% Cl)

P.value

Hausa

      

All malaria

76

57

0.4286

   

Clinical malaria

46

9

0.1636

   

Asymptomatic malaria

30

48

0.6515

8.178(3.504- 19.088)

2.133(1.58- 2.88)

< 0.0001

Population control

72

56

0.4357

3.975(1.795- 8.801)

1.412(1.186- 1.68)

0.0003

Massalit

      

All malaria

96

37

0.2782

   

Clinical malaria

70

16

0.1860

   

Asymptomatic malaria

26

21

0.4468

3.534 (1.602- 7.794)

2.096(1.360- 3.229)

0.001

Population control

97

55

0.3618

2.481(1.313- 4.686)

1.334(1.114- 1.597)

0.004