Skip to main content

Table 5 FAAH: results of a mutation screen in 92 German extremely obese children and adolescents

From: Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity

Gene

SNP

Position1

Location Exchange

Genotypes n (%)2,4

Allele frequency (%)3,4

FAAH

 

IVS1+22G/A

Intron 1

GG 31 (0.337)

G: 0.60

    

GA 49 (0.533)

 
    

AA 12 (0.130)

A: 0.40

FAAH

rs324420

c.385C/A

Exon 3

CC 82 (0.901)

C: 0.95

    

CA 09 (0.099)

 
   

Pro129Thr

AA 00 (0.000)

A: 0.05

FAAH

 

c.611C/T

Exon 5

CC 90 (0.989)

C: 0.99

    

CT 01 (0.011)

 
   

Thr204Ile

TT 00 (0.000)

T: 0.01

FAAH

 

c.690C/G

Exon 5

CC 90 (0.989)

C: 0.99

    

CG 01 (0.011)

 
   

Ser230Ser

GG 00 (0.000)

G: 0.01

FAAH

rs41305628

c.822G/A

Exon 6

GG 88 (0.957)

G: 0.98

    

GA 04 (0.043)

 
   

Glu274Glu

AA 00 (0.000)

A: 0.02

FAAH

rs41309147

IVS6-41G/A

Intron 6

GG 77 (0.837)

G: 0.92

    

GA 15 (0.163)

 
    

AA 00 (0.000)

A: 0.08

FAAH

rs324419

c.895C/T

Exon 7

CC 70 (0.761)

C: 0.88

    

CT 22 (0.239)

 
   

Cys299Cys

TT 00 (0.000)

T: 0.12

FAAH

 

IVS12-5C/T

Intron 12

CC 79 (0.859)

C: 0.93

    

CT 13 (0.141)

 
    

TT 00 (00.00)

T: 0.07

FAAH

rs2295632

IVS15+45G/T

3'UTR

GG 18 (0.196)

T: 0.60

    

GT 74 (0.804)

 
    

TT 00 (00.00)

G: 0.40

  1. 1 numbers are given according to Dunnen and Antonarakis 2001 Hum Genet 109:121-124 [33];2 genotype frequencies in the 92 individuals used for the mutation screen; 3 allele frequencies in the 92 individuals used for the mutation screen. 4 As the mutation screen was performed in those individuals who contributed to the initially observed overtransmission of the FAAH SNP rs2295632 G-allele, this SNP is therefore not in Hardy-Weinberg-Equilibrium in these samples.