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Table 3 Distribution of TYMS homozygote status for MTHFR homozygotes

From: Genetic selection? A study of individual variation in the enzymes of folate metabolism

 

TYMS

 

Cohort 1

Cohort 2

Cohort 3

Cohort 4

Cohort 5

MTHFR

2_2

Other

2_2

Other

2_2

Other

2_2

Other

2_2

Other

CC

131

355

50

156

53

126

39

127

41

144

TT

27

101

9

32

10

42

4

26

13

63

P*

 

0.11

 

0.46

 

0.09

 

0.16

 

0.23

Consensus P † 0.02 (all cohorts), 0.04 (cohorts 3, 4 and 5 only)

  1. * One-sided Fisher's exact test
  2. † Obtained using Stouffer's consensus combined P-value test [24]