Table 2 The MTHFR and TYMS genotype distributions, relative fitnesses and deviations from HWE of the genotypes in the 5 populations from Norfolk and Cumbria
From: Genetic selection? A study of individual variation in the enzymes of folate metabolism
MTHFR | Â | CC | CT | TT | Relative fitness CC vs CT | Relative fitness TT vs CT | Deviation from HWE |
|---|---|---|---|---|---|---|---|
Cohort 1 | Observed | 486.0 | 564.0 | 128.0 | 0.92 | 0.85 | 0.063 |
| Â | Expected | 500.7 | 534.6 | 142.7 | Â | Â | Â |
Cohort 2 | Observed | 206.0 | 191.0 | 41.0 | 0.98 | 0.95 | 0.824 |
| Â | Expected | 207.5 | 187.9 | 42.5 | Â | Â | Â |
Cohort 3 | Observed | 179.0 | 178.0 | 52.0 | 1.06 | 1.11 | 0.445 |
| Â | Expected | 175.6 | 184.8 | 48.6 | Â | Â | Â |
Cohort 4 | Observed | 166.0 | 202.0 | 30.0 | 0.81 | 0.61 | 0.003 |
| Â | Expected | 179.1 | 175.8 | 43.1 | Â | Â | Â |
Cohort 5 | Observed | 185.0 | 214.0 | 76.0 | 1.08 | 1.13 | 0.287 |
| Â | Expected | 179.5 | 225.0 | 70.5 | Â | Â | Â |
TYMS | Â | 3_3 | 2_3 | 2_2 | Relative fitness 3_3 vs 3_2 | Relative fitness 2_2 vs 3_2 | Deviation from HWE |
Cohort 1 | Observed | 350.0 | 541.0 | 287.0 | 1.16 | 1.18 | 0.007 |
| Â | Expected | 326.8 | 587.3 | 263.8 | Â | Â | Â |
Cohort 2 | Observed | 126.0 | 216.0 | 96.0 | 1.02 | 1.01 | 0.848 |
| Â | Expected | 125.0 | 218.0 | 95.0 | Â | Â | Â |
Cohort 3 | Observed | 129.0 | 180.0 | 100.0 | 1.24 | 1.28 | 0.022 |
| Â | Expected | 117.3 | 203.5 | 88.3 | Â | Â | Â |
Cohort 4 | Observed | 124.0 | 184.0 | 90.0 | 1.14 | 1.16 | 0.189 |
| Â | Expected | 117.2 | 197.6 | 83.2 | Â | Â | Â |
Cohort 5 | Observed | 146.0 | 240.0 | 89.0 | 0.96 | 0.94 | 0.641 |
| Â | Expected | 149.0 | 234.1 | 92.0 | Â | Â | Â |