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Table 5 Multiple linear regression analysis for AST, ALT, triglycerides, ferritin, hyaluronic acid, steatosis grade, and fibrosis stage

From: Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

Explanatory variable Subjects Independent variable β SE Pvalue
AST NAFLD Genotype (additive model, 0/1/2) 10.165 2.606 0.00013
   Age (year) -0.162 0.153 0.29
   Gender (Man/Women, 1/0) -4.967 4.335 0.25
   BMI (kg/m2) 0.711 0.380 0.063
  Control Genotype (additive model, 0/1/2) 0.567 0.466 0.23
   Age (year) 0.176 0.022 4.2 × 10-14
   Gender (Man/Women, 1/0) 0.226 0.775 0.77
   BMI (kg/m2) 0.120 0.167 0.47
ALT NAFLD Genotype (additive model, 0/1/2) 18.977 4.171 9.1 × 10-6
   Age (year) -1.125 0.244 7.1 × 10-6
   Gender (Man/Women, 1/0) 7.571 6.938 0.28
   BMI (kg/m2) 0.991 0.608 0.10
  Control Genotype (additive model, 0/1/2) 0.417 0.477 0.38
   Age (year) 0.120 0.023 2.5 × 10-7
   Gender (Man/Women, 1/0) 2.131 0.793 0.0076
   BMI (kg/m2) 0.370 0.171 0.031
Triglycerides NAFLD Genotype (additive model, 0/1/2) -0.050 0.017 0.0035
   Age (year) -0.003 0.001 0.0051
   Gender (Man/Women, 1/0) 0.102 0.023 0.00038
   BMI (kg/m2) -0.001 0.002 0.66
Ferritin NAFLD Genotype (additive model, 0/1/2) 0.107 0.043 0.014
   Age (year) 0.005 0.002 0.056
   Gender (Man/Women, 1/0) 0.298 0.069 2.9 × 10-5
   BMI (kg/m2) 0.009 0.006 0.11
Hyaluronic acid NAFLD Genotype (additive model, 0/1/2) 0.023 0.036 0.52
   Age (year) 0.016 0.002 1.6 × 10-12
   Gender (Man/Women, 1/0) -0.010 0.059 0.87
   BMI (kg/m2) 0.014 0.005 0.0047
Steatosis grade NAFLD Genotype (additive model, 0/1/2) 0.041 0.059 0.48
   Age (year) -0.010 0.003 0.0037
   Gender (Man/Women, 1/0) -0.106 0.098 0.28
   BMI (kg/m2) 0.022 0.009 0.010
Fibrosis stage NAFLD Genotype (additive model, 0/1/2) 0.211 0.082 0.011
   Age (year) 0.013 0.005 0.0058
   Gender (Man/Women, 1/0) 0.184 0.136 0.18
   BMI (kg/m2) 0.046 0.012 0.00016
  1. AST, aspartate transaminase; ALT, alanine transaminase; BMI, body mass index; NAFLD, nonalcoholic fatty liver disease. The values of triglycerides, ferritin, and hyaluronic acid were logarithmically transformed.
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BMC Medical Genetics

ISSN: 1471-2350

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