Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

Table 5 Multiple linear regression analysis for AST, ALT, triglycerides, ferritin, hyaluronic acid, steatosis grade, and fibrosis stage

Explanatory variable	Subjects	Independent variable	β	SE	Pvalue
AST	NAFLD	Genotype (additive model, 0/1/2)	10.165	2.606	0.00013
		Age (year)	-0.162	0.153	0.29
		Gender (Man/Women, 1/0)	-4.967	4.335	0.25
		BMI (kg/m²)	0.711	0.380	0.063
	Control	Genotype (additive model, 0/1/2)	0.567	0.466	0.23
		Age (year)	0.176	0.022	4.2 × 10^-14
		Gender (Man/Women, 1/0)	0.226	0.775	0.77
		BMI (kg/m²)	0.120	0.167	0.47
ALT	NAFLD	Genotype (additive model, 0/1/2)	18.977	4.171	9.1 × 10^-6
		Age (year)	-1.125	0.244	7.1 × 10^-6
		Gender (Man/Women, 1/0)	7.571	6.938	0.28
		BMI (kg/m²)	0.991	0.608	0.10
	Control	Genotype (additive model, 0/1/2)	0.417	0.477	0.38
		Age (year)	0.120	0.023	2.5 × 10^-7
		Gender (Man/Women, 1/0)	2.131	0.793	0.0076
		BMI (kg/m²)	0.370	0.171	0.031
Triglycerides	NAFLD	Genotype (additive model, 0/1/2)	-0.050	0.017	0.0035
		Age (year)	-0.003	0.001	0.0051
		Gender (Man/Women, 1/0)	0.102	0.023	0.00038
		BMI (kg/m²)	-0.001	0.002	0.66
Ferritin	NAFLD	Genotype (additive model, 0/1/2)	0.107	0.043	0.014
		Age (year)	0.005	0.002	0.056
		Gender (Man/Women, 1/0)	0.298	0.069	2.9 × 10^-5
		BMI (kg/m²)	0.009	0.006	0.11
Hyaluronic acid	NAFLD	Genotype (additive model, 0/1/2)	0.023	0.036	0.52
		Age (year)	0.016	0.002	1.6 × 10^-12
		Gender (Man/Women, 1/0)	-0.010	0.059	0.87
		BMI (kg/m²)	0.014	0.005	0.0047
Steatosis grade	NAFLD	Genotype (additive model, 0/1/2)	0.041	0.059	0.48
		Age (year)	-0.010	0.003	0.0037
		Gender (Man/Women, 1/0)	-0.106	0.098	0.28
		BMI (kg/m²)	0.022	0.009	0.010
Fibrosis stage	NAFLD	Genotype (additive model, 0/1/2)	0.211	0.082	0.011
		Age (year)	0.013	0.005	0.0058
		Gender (Man/Women, 1/0)	0.184	0.136	0.18
		BMI (kg/m²)	0.046	0.012	0.00016

AST, aspartate transaminase; ALT, alanine transaminase; BMI, body mass index; NAFLD, nonalcoholic fatty liver disease. The values of triglycerides, ferritin, and hyaluronic acid were logarithmically transformed.

ISSN: 1471-2350