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Table 4 Comparison of various quantitative phenotypes among the different genotypes at rs738409 in PNPLA3 in patients with NAFLD and control subjects

From: Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

Quantitative phenotype

 

NAFLD *

   

Control *

  
 

CC (n = 45)

CG (n = 111)

GG (n = 97)

Pvalue§

CC (n = 175)

CG (n = 296)

GG (n = 104)

Pvalue§

Age (year)

53.4 ± 11.2

48.6 ± 15.0

54.5 ± 16.0

0.019

45.6 ± 14.9

47.6 ± 14.5

48.9 ± 15.7

0.17

BMI (kg/m2)

26.8 ± 4.9

28.0 ± 4.4

27.8 ± 6.3

0.16

21.2 ± 2.2

21.4 ± 2.1

21.4 ± 2.0

0.75

FBS (mg/dL)

121.2 ± 28.7

117.5 ± 38.2

114.5 ± 33.1

0.014

90.0 ± 7.8

91.4 ± 7.6

90.7 ± 7.4

0.23

HbA1c (%)

6.0 ± 1.2

5.9 ± 1.3

5.8 ± 1.1

0.36

5.0 ± 0.3

5.0 ± 0.4

5.1 ± 0.3

0.78

Total cholesterol (mg/dL)

217.4 ± 32.8

209.7 ± 40.6

212.6 ± 37.2

0.38

198.6 ± 34.0

203.7 ± 33.7

203.6 ± 36.6

0.25

Triglycerides (mg/dL)

175.3 ± 81.4

188.0 ± 119.5

146.2 ± 69.0

0.0055

75.7 ± 29.1

76.5 ± 29.0

72.9 ± 27.0

0.56

HDL cholesterol (mg/dL)

54.6 ± 21.0

50.6 ± 17.6

53.7 ± 15.0

0.20

65.4 ± 13.3

68.0 ± 13.9

69.1 ± 14.9

0.073

SBP (mm Hg)

128.3 ± 14.8

127.0 ± 16.0

125.6 ± 15.5

0.61

109.6 ± 10.6

112.1 ± 10.0

110.3 ± 9.7

0.033

DBP (mm Hg)

78.9 ± 11.4

77.1 ± 12.4

77.3 ± 10.2

0.88

68.6 ± 7.9

70.0 ± 7.4

69.2 ± 7.2

0.16

AST (IU/L)

34.0 ± 14.6

47.5 ± 26.4

57.5 ± 35.5

0.00017

19.3 ± 6.5

19.6 ± 6.5

21.2 ± 5.8

0.047

ALT (IU/L)

48.3 ± 24.6

76.9 ± 48.9

89.6 ± 57.0

4.7 × 10-5

15.1 ± 5.5

15.5 ± 6.9

16.4 ± 6.2

0.36

Iron (ng/mL)

112.4 ± 28.7

106.1 ± 34.7

113.9 ± 33.1

0.66

--

--

--

--

Ferritin (ng/mL)

168.8 ± 124.4

271.2 ± 268.6

276.3 ± 224.7

0.038

--

--

--

--

Hyaluronic acid (ng/dL)

48.4 ± 47.4

39.7 ± 55.3

57.3 ± 74.0

0.022

--

--

--

--

Type IV collagen 7S (ng/dL)

4.6 ± 1.9

4.6 ± 1.4

4.6 ± 1.2

0.76

--

--

--

--

Steatosis grade

1.5 ± 0.6

1.6 ± 0.7

1.6 ± 0.6

0.57

--

--

--

--

Fibrosis stage

0.7 ± 0.8

1.1 ± 0.9

1.2 ± 1.0

0.013

--

--

--

--

  1. Data are represented as the mean ± SD. AST, aspartate transaminase; ALT, alanine transaminase; BMI, body mass index; DBP, diastolic blood pressure; FBS, fasting blood sugar; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; NAFLD, nonalcoholic fatty liver disease; SBP, systolic blood pressure. * The data of each quantitative phenotype from NAFLD and control subjects were compared for the different rs738409 genotypes in patients with NAFLD and control subjects. § P values were analyzed using the Kruskal-Wallis test in each group of NAFLD and control subjects.
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BMC Medical Genetics

ISSN: 1471-2350

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