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Table 4 Comparison of various quantitative phenotypes among the different genotypes at rs738409 in PNPLA3 in patients with NAFLD and control subjects

From: Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

Quantitative phenotype   NAFLD *     Control *   
  CC (n = 45) CG (n = 111) GG (n = 97) Pvalue§ CC (n = 175) CG (n = 296) GG (n = 104) Pvalue§
Age (year) 53.4 ± 11.2 48.6 ± 15.0 54.5 ± 16.0 0.019 45.6 ± 14.9 47.6 ± 14.5 48.9 ± 15.7 0.17
BMI (kg/m2) 26.8 ± 4.9 28.0 ± 4.4 27.8 ± 6.3 0.16 21.2 ± 2.2 21.4 ± 2.1 21.4 ± 2.0 0.75
FBS (mg/dL) 121.2 ± 28.7 117.5 ± 38.2 114.5 ± 33.1 0.014 90.0 ± 7.8 91.4 ± 7.6 90.7 ± 7.4 0.23
HbA1c (%) 6.0 ± 1.2 5.9 ± 1.3 5.8 ± 1.1 0.36 5.0 ± 0.3 5.0 ± 0.4 5.1 ± 0.3 0.78
Total cholesterol (mg/dL) 217.4 ± 32.8 209.7 ± 40.6 212.6 ± 37.2 0.38 198.6 ± 34.0 203.7 ± 33.7 203.6 ± 36.6 0.25
Triglycerides (mg/dL) 175.3 ± 81.4 188.0 ± 119.5 146.2 ± 69.0 0.0055 75.7 ± 29.1 76.5 ± 29.0 72.9 ± 27.0 0.56
HDL cholesterol (mg/dL) 54.6 ± 21.0 50.6 ± 17.6 53.7 ± 15.0 0.20 65.4 ± 13.3 68.0 ± 13.9 69.1 ± 14.9 0.073
SBP (mm Hg) 128.3 ± 14.8 127.0 ± 16.0 125.6 ± 15.5 0.61 109.6 ± 10.6 112.1 ± 10.0 110.3 ± 9.7 0.033
DBP (mm Hg) 78.9 ± 11.4 77.1 ± 12.4 77.3 ± 10.2 0.88 68.6 ± 7.9 70.0 ± 7.4 69.2 ± 7.2 0.16
AST (IU/L) 34.0 ± 14.6 47.5 ± 26.4 57.5 ± 35.5 0.00017 19.3 ± 6.5 19.6 ± 6.5 21.2 ± 5.8 0.047
ALT (IU/L) 48.3 ± 24.6 76.9 ± 48.9 89.6 ± 57.0 4.7 × 10-5 15.1 ± 5.5 15.5 ± 6.9 16.4 ± 6.2 0.36
Iron (ng/mL) 112.4 ± 28.7 106.1 ± 34.7 113.9 ± 33.1 0.66 -- -- -- --
Ferritin (ng/mL) 168.8 ± 124.4 271.2 ± 268.6 276.3 ± 224.7 0.038 -- -- -- --
Hyaluronic acid (ng/dL) 48.4 ± 47.4 39.7 ± 55.3 57.3 ± 74.0 0.022 -- -- -- --
Type IV collagen 7S (ng/dL) 4.6 ± 1.9 4.6 ± 1.4 4.6 ± 1.2 0.76 -- -- -- --
Steatosis grade 1.5 ± 0.6 1.6 ± 0.7 1.6 ± 0.6 0.57 -- -- -- --
Fibrosis stage 0.7 ± 0.8 1.1 ± 0.9 1.2 ± 1.0 0.013 -- -- -- --
  1. Data are represented as the mean ± SD. AST, aspartate transaminase; ALT, alanine transaminase; BMI, body mass index; DBP, diastolic blood pressure; FBS, fasting blood sugar; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; NAFLD, nonalcoholic fatty liver disease; SBP, systolic blood pressure. * The data of each quantitative phenotype from NAFLD and control subjects were compared for the different rs738409 genotypes in patients with NAFLD and control subjects. § P values were analyzed using the Kruskal-Wallis test in each group of NAFLD and control subjects.