Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

Table 3 Genotype frequencies and association tests of rs738409 in PNPLA3 in patients with NAFLD and control subjects

	Genotype CC/CG/GG	Risk allele (G) frequency	Pvalue (additive model)			OR (95% CI)			HWE
			Unadjusted	Adjusted for age and gender	Adjusted for age, gender and BMI	Heterogyotes	Homogyotes	Additive model *	Pvalue
NAFLD vs. control
NAFLD	45/111/97	0.60	9.4 × 10^-10	1.9 × 10^-8	0.00087	1.46 (0.98 - 2.16)	3.63 (2.36 - 5.57)	1.73 (1.25 - 2.38)	0.18
Control	175/296/104	0.44							0.28
NASH vs. control
NASH	26/85/78	0.64	1.8 × 10^-11	5.7 × 10^-10	0.00082	1.93 (1.20 - 3.12)	5.05 (3.04 - 8.37)	2.00 (1.33 - 3.00)	0.71
Control	175/296/104	0.44							0.28
NASH vs. simple steatosis
NASH	26/85/78	0.64	0.0083	0.010	0.021	2.39 (1.14 - 4.99)	3.00 (1.38 - 6.51)	1.65 (1.08 - 2.51)	0.71
Simple steatosis	19/26/19	0.50							0.13
Simple steatosis vs. control
Simple steatosis	19/26/19	0.50	0.18	0.24	0.16	0.81 (0.44 - 1.50)	1.68 (0.85 - 3.32)	1.37 (0.88 - 2.14)	0.13
Control	175/296/104	0.44							0.28

CI, confidence interval; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; HWE, Hardy-Weinberg equilibrium; OR, odds ratio. * The OR was adjusted simultaneously for age, gender, and BMI using the additive model.

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