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Table 2 Clinical characteristics of patients with NASH and simple steatosis

From: Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

  NASH (n = 189) Simple steatosis (n = 64) Pvalue
Men/women 99/90 23/41 0.030*
Age (year) 51.8 ± 15.7 (37.0; 52.5; 65.0) 51.3 ± 13.1 (44.0; 52.5; 61.0) 0.93
BMI (kg/m2) 28.5 ± 5.6 (25.3; 28.1; 30.4) 25.3 ± 3.5 (22.4; 24.7; 27.5) <0.0001
FBS (mg/dL) 116.7 ± 31.5 (100.0; 108.0; 124.0) 118.0 ± 41.7 (95.8; 105.5; 122.0) 0.27
HbA1c (%) 5.9 ± 1.2 (5.1; 5.6; 6.3) 5.8 ± 1.3 (5.0; 5.3; 6.3) 0.22
Total cholesterol (mg/dL) 210.0 ± 37.3 (183.0; 210.0; 232.0) 218.0 ± 39.0 (189.5; 217.0; 249.0) 0.12
Triglycerides (mg/dL) 174.6 ± 103.9 (115.0; 149.0; 211.0) 158.2 ± 80.0 (104.0; 147.0; 195.5) 0.29
HDL cholesterol (mg/dL) 51.7 ± 18.1 (41.0; 48.0; 57.3) 54.6 ± 15.5 (44.0; 54.0; 60.5) 0.049
Systolic blood pressure (mm Hg) 127.8 ± 15.4 (118.0; 126.0; 140.0) 124.2 ± 15.7 (111.0; 124.0; 137.0) 0.13
Diastolic blood pressure (mm Hg) 77.8 ± 11.3 (70.0; 78.0; 85.0) 76.9 ± 11.9 (68.5; 76.0; 87.0) 0.58
AST (IU/L) 55.2 ± 31.3 (32.0; 45.0; 69.0) 32.5 ± 16.8 (21.0; 27.0; 36.3) <0.0001
ALT (IU/L) 87.0 ± 53.2 (51.0; 76.0; 103.0) 49.7 ± 31.1 (30.8; 41.0; 47.3) <0.0001
Iron (ng/mL) 111.7 ± 35.5 (91.0; 114.5; 134.0) 106.1 ± 26.1 (85.5; 100.0; 123.8) 0.087
Ferritin (ng/mL) 278.1 ± 246.5 (98.0; 204.4; 379.0) 181.2 ± 172.5 (84.0; 131.0; 175.2) 0.0036
Hyaluronic acid (ng/dL) 54.0 ± 68.5 (16.0; 32.0; 75.0) 26.7 ± 20.5 (9.0; 23.0; 36.5) 0.0048
Type IV collagen 7S (ng/dL) 4.9 ± 1.5 (3.9; 4.7; 5.5) 3.8 ± 0.7 (3.5; 3.7; 4.1) <0.0001
Steatosis grade 1.7 ± 0.7 (1.0; 2.0; 2.0) 1.3 ± 0.5 (1.0; 1.0; 2.0) <0.0001
Fibrosis stage 1.4 ± 0.8 (1.0; 1.0; 2.0) 0.1 ± 0.4 (0.0; 0.0; 0.0) <0.0001
  1. Data are represented as the mean ± SD (25th, 50th, and 75th percentile). P values were obtained by comparing the quantitative phenotype between 2 groups (Mann-Whitney U test). *Men/women ratio was analyzed by Fisher's exact test. AST, aspartate transaminase; ALT, alanine transaminase; BMI, body mass index; FBS, fasting blood sugar; HbA1c, hemoglobin A1c; HDL; high-density lipoprotein; NASH, nonalcoholic steatohepatitis.