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Table 2 Clinical characteristics of patients with NASH and simple steatosis

From: Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

 

NASH

(n = 189)

Simple steatosis (n = 64)

Pvalue

Men/women

99/90

23/41

0.030*

Age (year)

51.8 ± 15.7

(37.0; 52.5; 65.0)

51.3 ± 13.1

(44.0; 52.5; 61.0)

0.93

BMI (kg/m2)

28.5 ± 5.6

(25.3; 28.1; 30.4)

25.3 ± 3.5

(22.4; 24.7; 27.5)

<0.0001

FBS (mg/dL)

116.7 ± 31.5

(100.0; 108.0; 124.0)

118.0 ± 41.7

(95.8; 105.5; 122.0)

0.27

HbA1c (%)

5.9 ± 1.2

(5.1; 5.6; 6.3)

5.8 ± 1.3

(5.0; 5.3; 6.3)

0.22

Total cholesterol (mg/dL)

210.0 ± 37.3

(183.0; 210.0; 232.0)

218.0 ± 39.0

(189.5; 217.0; 249.0)

0.12

Triglycerides (mg/dL)

174.6 ± 103.9

(115.0; 149.0; 211.0)

158.2 ± 80.0

(104.0; 147.0; 195.5)

0.29

HDL cholesterol (mg/dL)

51.7 ± 18.1

(41.0; 48.0; 57.3)

54.6 ± 15.5

(44.0; 54.0; 60.5)

0.049

Systolic blood pressure (mm Hg)

127.8 ± 15.4

(118.0; 126.0; 140.0)

124.2 ± 15.7

(111.0; 124.0; 137.0)

0.13

Diastolic blood pressure (mm Hg)

77.8 ± 11.3

(70.0; 78.0; 85.0)

76.9 ± 11.9

(68.5; 76.0; 87.0)

0.58

AST (IU/L)

55.2 ± 31.3

(32.0; 45.0; 69.0)

32.5 ± 16.8

(21.0; 27.0; 36.3)

<0.0001

ALT (IU/L)

87.0 ± 53.2

(51.0; 76.0; 103.0)

49.7 ± 31.1

(30.8; 41.0; 47.3)

<0.0001

Iron (ng/mL)

111.7 ± 35.5

(91.0; 114.5; 134.0)

106.1 ± 26.1

(85.5; 100.0; 123.8)

0.087

Ferritin (ng/mL)

278.1 ± 246.5

(98.0; 204.4; 379.0)

181.2 ± 172.5

(84.0; 131.0; 175.2)

0.0036

Hyaluronic acid (ng/dL)

54.0 ± 68.5

(16.0; 32.0; 75.0)

26.7 ± 20.5

(9.0; 23.0; 36.5)

0.0048

Type IV collagen 7S (ng/dL)

4.9 ± 1.5

(3.9; 4.7; 5.5)

3.8 ± 0.7

(3.5; 3.7; 4.1)

<0.0001

Steatosis grade

1.7 ± 0.7

(1.0; 2.0; 2.0)

1.3 ± 0.5

(1.0; 1.0; 2.0)

<0.0001

Fibrosis stage

1.4 ± 0.8

(1.0; 1.0; 2.0)

0.1 ± 0.4

(0.0; 0.0; 0.0)

<0.0001

  1. Data are represented as the mean ± SD (25th, 50th, and 75th percentile). P values were obtained by comparing the quantitative phenotype between 2 groups (Mann-Whitney U test). *Men/women ratio was analyzed by Fisher's exact test. AST, aspartate transaminase; ALT, alanine transaminase; BMI, body mass index; FBS, fasting blood sugar; HbA1c, hemoglobin A1c; HDL; high-density lipoprotein; NASH, nonalcoholic steatohepatitis.
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BMC Medical Genetics

ISSN: 1471-2350

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