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Table 4 Composite genotype associations with colon and rectal cancer from hapConstructor and from multivariable-adjusted logistic regression

From: Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor

    

Genetic

hapConstructor*

Logistic regression**

SNP 1

SNP 2

SNP 3

SNP1/SNP2/SNP3 genotype

Model

OR

P

OR

95%CI

Colon study

        

IKBKB rs3747811

NFKB1 rs4648110

 

(TA or AA)/AA

Dom./Rec.

0.56

0.0094

0.54

0.34, 0.87

IL6 rs2069827

NFKB1 rs4648110

 

(GT or TT)/AA

Dom./Rec.

0.23

0.0058

0.21

0.06, 0.74

IL6 rs1800797

NFKB1 rs4648110

 

(GA or AA)/AA

Dom./Rec.

0.41

0.0004

0.40

0.23, 0.72

IKBKB rs5029748

IL6 rs1800797

NFKB1 rs4648110

(CA or AA)/(GA or AA)/AA

Dom./Dom./Rec.

0.21

0.0004

0.20

0.06, 0.67

IL6 rs1800797

NFKB1 rs4648090

NFKB1 rs4648110

(GA or AA)/(GA or AA)/AA

Dom./Dom./Rec.

0.40

0.0004

0.40

0.21, 0.73

IL6 rs1800797

NFKB1 rs13117745

NFKB1 rs4648110

(GA or AA)/(GA or AA)/AA

Dom./Dom./Rec.

0.39

0.0002

0.39

0.21, 0.73

Rectal study

        

IKBKB rs3747811

NFKB1 rs11722146

 

(TA or AA)/(GA or AA)

Dom./Dom.

1.30

0.0096

1.11

0.83, 1.50

IL6 rs1800797

NFKB1 rs11722146

 

(GA or AA)/(GA or AA)

Dom./Dom.

1.35

0.0068

1.38

1.04, 1.83

IL6 rs1800797

NFKB1 rs3821958

 

(GA or AA)/(AG or GG)

Dom./Dom.

1.34

0.0044

1.15

0.85, 1.56

  1. NOTES: Odds ratio (OR); 95% confidence interval (95%CI); Dominant (Dom); Recessive (Rec)
  2. *adjusted for race; reference category is all other composite genotypes
  3. **adjusted for age, sex, center, and race; reference category is major allele homozygote (dominant) or heterozygote (recessive) for each SNP
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BMC Medical Genetics

ISSN: 1471-2350

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