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Table 2 Single SNP results from hapConstructor and from multivariable-adjusted logistic regression

From: Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor

   

Genetic

hapConstructor*

Logistic regression**

Gene

SNP

Comparison

Model

OR

P

OR

95%CI

Colon study

      

IL6

rs2069860

AT/TT vs. AA

Dominant

0.53

0.02

0.55

0.32, 0.95

IKBKB

rs2272733

TT vs. CC

Additive

0.55

0.02

0.56

0.34, 0.93

NFKB1

rs4648110

AA vs. TT

Additive

0.63

0.01

0.65

0.44, 0.94

  

AA vs. TT/TA

Recessive

0.64

0.01

0.66

0.45, 0.96

 

rs13117745

TT vs. CC

Additive

0.61

0.03

0.61

0.37, 1.00

  

TT vs. CC/CT

Recessive

0.62

0.04

0.64

0.39, 1.04

Rectal study

      

NFKB1

rs230510

TT vs. AA

Additive

0.66

0.004

0.65

0.49, 0.87

  

TT vs. AA/AT

Dominant

0.77

0.009

0.79

0.51, 0.94

 

rs3821958

GG vs. AA

Additive

1.34

0.04

1.32

1.00, 1.75

 

rs11722146

GA/AA vs. GG

Dominant

1.21

0.047

1.24

1.03, 1.51

 

rs13117745

TT vs. CC

Additive

1.92

0.04

1.69

0.93, 3.07

  1. NOTES: Odds ratios (ORs) compared to reference of major allele homozygotes; 95% confidence interval (95% CI)
  2. *adjusted for race
  3. **adjusted for age, sex, center, and race
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BMC Medical Genetics

ISSN: 1471-2350

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