Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury

BMC Medical Genetics

Table 3 Association analysis of haplotypes in TIRAP between different groups

Haplotypes	Healthy control	Acute lung injury	Sepsis alone	P^a	OR^a(95% CI)	P^b	OR^b(95% CI)
rs595209, rs8177375	(Frequency)	(Frequency)	(Frequency)
Global test				0.015		0.011
				0.016*		0.014*
CA	0.678	0.602	0.686	0.0003	0.69 (0.54-0.88)	0.0006	0.71 (0.55-0.91)
				0.00057*	0.75 (0.60-0.91)*	0.0009*	0.72 (0.54-0.93)*
AA	0.224	0.228	0.218	0.65	1.07 (0.81-1.41)	0.78	1.04 (0.79-1.38)
				0.52*	1.12 (0.87-2.17)*	0.42*	1.21 (0.54-2.06)*
AG	0.076	0.157	0.080	0.00006	2.13 (1.46-3.09)	0.00003	2.24 (1.52-3.29)
				0.0002*	1.78 (1.35-2.92)*	0.0004*	2.09 (1.41-3.01)*

OR, odds ratio; CI, confidence interval.
P^a and OR^a , acute lung injury vs healthy control; P^b and OR^b , acute lung injury vs sepsis alone.
* The adjusted P-value and OR in multiple logistic regression after adjustment for clinical variables.
A P-value of < 0.025 (0.05/2) was considered statistically significant after Bonferroni correction. Haplotypes CA and AG remained significant after Bonferroni correction.

ISSN: 1471-2350