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Table 2 Association analysis of the five SNPs in TIRAP between different groups

From: Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury

SNP

Reference

Acute lung injury patients vs. Healthy controls

Acute lung injury patients vs. Sepsis alone patients

 

allele

OR ( 95% CI)

Pa

Pb

OR (95%CI)

Pa

Pb

rs595209

A

1.47 (1.15-1.88)

0.0027

0.0034

1.44 (1.12-1.85)

0.0041

0.0084

  

1.43 (1.12-1.82)*

0.0036*

0.0041*

1.36 (1.07-2.02)*

0.0082*

0.0095*

rs3802813

A

1.13 (0.83-1.55)

0.44

0.34

1.03 (0.75-1.41)

0.85

0.61

  

1.10 (0.80-1.45)*

0.56*

0.48*

1.01 (0.61-1.24)*

0.91*

0.69*

rs8177374

T

1.43 (0.49-4.14)

0.51

0.59

1.67 (0.54-5.13)

0.85

0.41

  

1.28 (0.41-4.34)*

0.63*

0.75*

1.41 (0.51-4.93)*

0.92*

0.55*

rs7932766

T

0.49 (0.21-1.15)

0.095

0.091

0.58 (0.24-1.40)

0.22

0.28

  

0.56 (0.28-1.25)*

0.19*

0.23*

0.51 (0.20-1.34)*

0.28*

0.39*

rs8177375

G

1.97 (1.38-2.80)

0.0001

0.00047

1.82 (1.28-2.57)

0.00079

0.0026

  

1.81 (1.30-2.69)*

0.00031*

0.00098*

1.51 (1.15-3.04)*

0.0041*

0.0083*

  1. SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
  2. Pa, allelic P value; Pb, genotypic P value.
  3. * The adjusted P-value and OR in multiple logistic regression after adjustment for clinical variables.
  4. A P-value of < 0.01 (0.05/5) was considered statistically significant after Bonferroni correction. Rs595209 and rs8177375 remained significant after Bonferroni correction.
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BMC Medical Genetics

ISSN: 1471-2350

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