BMC Medical Genetics

Table 2 Risk of OA according to rs1256031 (tSNP2) genotypes in the Rotterdam Study-I

From: Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis

		Women Rotterdam Study-I			Men Rotterdam Study-I
Phenotype	Genotype	Nr cases/total ¹ (%)	OR (95% CI) ²	p-value	Nr cases/total ¹ (%)	OR (95% CI) ²	p-value
Hip OA	TT	43/534 (8.1)	1.36 (1.08-1.70)	0.009	34/408 (8.3)	1.01 (0.77-1.33)	0.93
	TC	80/861 (9.3)			58/621 (9.3)
	CC	46/363 (12.7)			23/269 (8.6)
Knee OA	TT	122/477 (25.6)	1.09 (0.93-1.28)	0.30	60/344 (17.4)	0.85 (0.67-1.07)	0.16
	TC	272/837 (32.5)			83/503 (16.5)
	CC	98/346 (28.3)			30/233 (12.9)
Hand OA	TT	172/510 (33.7)	1.13 (0.97-1.30)	0.11	83/418 (19.9)	0.95 (0.78-1.15)	0.58
	TC	300/836 (35.9)			134/644 (20.8)
	CC	131/359 (36.5)			54/291 (18.6)

¹ Number of cases/total number of subjects with radiographs scored for the presence of OA; ²additive model adjusted for age and BMI

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