The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

Table 6 Odds ratios of AD for the DBH and IL1A variants*, when stratified by each other

Odds ratio of AD for:-	In the subset:-	Numbers		Adjusted^† odds ratio of AD (95% CI, p)
		Controls	AD
DBH -1021TT+TC	IL1A -889TC+CC	CC: 3546	CC: 862	1.1 (0.99-1.3, 0.07)
vs CC		TT+TC: 2077	TT+TC: 516
	IL1A -889TT	CC: 340	CC: 87	2.25 (1.4-3.6, 0.0008)
		TT+TC: 174	TT+TC: 70
IL1A -889TT	DBH -1021CC	TC+CC: 3546	TC+CC: 862	0.95 (0.7-1.3, 0.76)
vs TC+CC		TT: 340	TT: 87
	DBH -1021TT+TC	TC+CC: 2077	TC+CC: 516	1.8 (1.3-2.6, 0.0009)
		TT: 174	TT: 70

AD = Alzheimer's disease, DBH = dopamine β-hydroxylase, IL1A = interleukin-1α, CI = confidence interval.
* DBH -1021TT+TC vs CC and IL1A -889TT vs TC+CC
^† All analyses controlled for centre, age, sex and genotype of apolipoprotein E ε4.
Results in bold are significant at p < 0.05.

ISSN: 1471-2350