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Table 2 Interactions of DBH -1021TT+TC versus CC with sex and age in AD risk

From: The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

Interaction

Dataset

Numbers

Power*

Adjusted synergy factor (95% CI, p)

  

Controls

AD

  

With sex

All

6201

1611

88%

1.4 (1.1-1.9, 0.01)

 

North Europe

5708

1109

78%

1.6 (1.1-2.1, 0.006)

 

North Spain

493

502

32%

1.3 (0.7-2.5, 0.4)

With age

All

6200

1611

85%

1.4 (1.04-1.9, 0.03)

(± 75 years)

North Europe

5708

1109

73%

1.3 (0.9-1.8, 0.2)

 

North Spain

492

502

32%

2.1 (1.1-3.9, 0.02)

  1. DBH = dopamine β-hydroxylase, AD = Alzheimer's disease, CI = confidence interval.
  2. * power to detect a synergy factor of 1.4, as in the overall dataset, at p < 0.05.
  3. All analyses controlled for centre, age, sex and genotype of apolipoprotein E ε4.
  4. Results in bold are significant at p < 0.05.