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The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

  • Onofre Combarros1Email author,
  • Donald R Warden2,
  • Naomi Hammond3,
  • Mario Cortina-Borja4,
  • Olivia Belbin5,
  • Michael G Lehmann2,
  • Gordon K Wilcock6,
  • Kristelle Brown5,
  • Patrick G Kehoe7,
  • Rachel Barber7,
  • Eliecer Coto8,
  • Victoria Alvarez8,
  • Panos Deloukas3,
  • Rhian Gwilliam3,
  • Reinhard Heun9, 10,
  • Heike Kölsch9,
  • Ignacio Mateo1,
  • Abderrahim Oulhaj11,
  • Alejandro Arias-Vásquez12, 13,
  • Maaike Schuur12, 14,
  • Yurii S Aulchenko12,
  • M Arfan Ikram12,
  • Monique M Breteler12,
  • Cornelia M van Duijn12,
  • Kevin Morgan5,
  • A David Smith2 and
  • Donald J Lehmann2
BMC Medical Genetics201011:162

https://doi.org/10.1186/1471-2350-11-162

Received: 4 June 2010

Accepted: 11 November 2010

Published: 11 November 2010

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Open Peer Review reports

Pre-publication versions of this article are available by contacting info@biomedcentral.com.

Original Submission
4 Jun 2010 Submitted Original manuscript
10 Aug 2010 Reviewed Reviewer Report - Benedetta Nacmias
18 Aug 2010 Reviewed Reviewer Report - Rita Guerreiro
28 Aug 2010 Reviewed Reviewer Report - Joseph Cubells
26 Sep 2010 Author responded Author comments - Onofre Combarros
Resubmission - Version 2
26 Sep 2010 Submitted Manuscript version 2
12 Oct 2010 Reviewed Reviewer Report - Benedetta Nacmias
26 Oct 2010 Reviewed Reviewer Report - Rita Guerreiro
27 Oct 2010 Reviewed Reviewer Report - Joseph Cubells
7 Nov 2010 Author responded Author comments - Onofre Combarros
Resubmission - Version 3
7 Nov 2010 Submitted Manuscript version 3
11 Nov 2010 Author responded Author comments - Onofre Combarros
Resubmission - Version 4
11 Nov 2010 Submitted Manuscript version 4
Publishing
11 Nov 2010 Editorially accepted
11 Nov 2010 Article published 10.1186/1471-2350-11-162

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Marqués de Valdecilla University Hospital (University of Cantabria), Santander, Spain
(2)
Oxford Project to Investigate Memory and Ageing (OPTIMA), University Department of Physiology, Anatomy and Genetics, Oxford, UK
(3)
The Wellcome Trust Sanger Institute, Hinxton, UK
(4)
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
(5)
School of Molecular Medical Sciences, Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, UK
(6)
Nuffield Department of Medicine, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, UK
(7)
Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Frenchay Bristol, UK
(8)
Genética Molecular, Hospital Central de Asturias, Oviedo, Spain
(9)
Department of Psychiatry, University of Bonn, Bonn, Germany
(10)
Royal Derby Hospital, Derby, UK
(11)
OPTIMA, Nuffield Department of Medicine, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, UK
(12)
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
(13)
Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior & Department of Human Genetics, Radboud University Nijmegen, Medical Centre, HP 966, Nijmegen, The Netherlands
(14)
Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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