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Table 3 Association between DC-SIG N promoter variants and NPC

From: Sequencing of DC-SIGN promoter indicates an association between promoter variation and risk of nasopharyngeal carcinoma in cantonese

SNP

Genotype

Case

Control

UnadjustedOR (95% CI)*

Unadjusted P-value*

Adjusted OR (95% CI) #

Adjusted P-value #

DC-SIGN -116

GG

440

457

ref

 

ref

 
 

GT

4

7

0.59(0.17-2.04)

0.40

0.57 (0.16-2.01)

0.38

 

TT

0

0

--

--

--

--

Allele

G

884

921

ref

   
 

T

4

7

0.60(0.17-2.04)

0.40

--

--

DC-SIGN -139

AA

212

268

ref

 

ref

 
 

AG

188

168

1.42 (1.07-1.86)

0.01

1.41 (1.05-1.88)

0.02

 

GG

44

28

1.99 (1.20-3.30)

0.007

2.10 (1.23-3.59)

0.006

       

P trend = 0.005

Allele

A

612

704

ref

   
 

G

276

224

1.42 (1.15-1.74)

0.001

--

--

DC-SIGN -190

AA

441

462

ref

 

ref

 
 

AG

3

2

1.57 (0.26-9.45)

0.68

1.57 (0.24-10.36)

0.64

 

GG

0

0

--

--

--

--

Allele

A

885

926

ref

   
 

G

3

2

1.57 (0.26-9.42)

0.68

--

--

DC-SIGN -336

AA

365

396

ref

 

ref

 
 

AG

77

63

1.33 (0.92-1.91)

0.13

1.43 (0.98-2.09)

0.07

 

GG

2

5

0.43 (0.08-2.25)

0.45

0.57 (0.11-3.07)

0.51

       

P trend = 0.14

Allele

A

807

855

ref

   
 

G

81

73

1.18 (0.85-1.64)

0.34

--

--

DC-SIGN -871

AA

301

352

ref

 

ref

 
 

AG

127

104

1.43(1.06-1.93)

0.02

1.44 (1.05-1.98)

0.03

 

GG

16

8

2.34 (0.99-5.54)

0.05

1.97 (0.80-4.88)

0.14

       

P trend = 0.04

Allele

A

729

808

ref

   
 

G

159

120

1.47 (1.14-1.90)

0.003

--

--

DC-SIGN -939

GG

251

301

ref

 

ref

 
 

AG

161

148

1.31 (0.99-1.72)

0.06

1.28 (0.95-1.71)

0.11

 

AA

32

15

2.56 (1.36-4.83)

0.003

2.52 (1.29-4.93)

0.007

       

P trend = 0.01

Allele

G

663

750

ref

   
 

A

225

178

1.43 (1.15-1.79)

0.002

--

--

  1. * Odds ratios and P- values were calculated using the chi-square test.
  2. # Odds ratios and P-Values were calculated by adjusting for age, sex, educational level.