SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in african-americans of the GENOA study

Table 1 Descriptive statistics for the full African-American cohort of GENOA and two internal replication subset samples.

		Full Sample		Subset 1		Subset 2
Variable	N	Mean ± St. Dev.	N	Mean ± St. Dev.	N	Mean ± St. Dev.
Age, years.	1328	62.7 ± 9.5	491	62.99 ± 9.63	496	63.09 ± 9.62
BMI, kg/m²	1326	31.5 ± 6.6	488	31.67 ± 7.01	494	31.5 ± 6.88
SBP, mmHg	1328	138.3 ± 21.1	491	139.3 ± 21.49	496	138.5 ± 20.77
DBP, mmHg	1328	79.6 ± 10.8	491	80.28 ± 10.76	496	79.92 ± 11.35
Height, cm	1326	168.4 ± 8.8	488	169.4 ± 9.15	494	169.2 ± 9.08
Weight, kg	1326	89.3 ± 19	488	90.66 ± 19.83	494	90.01 ± 19.5
Duration of hypertension, years	1046	16.5 ± 12.8	404	16.79 ± 13.24	396	16.17 ± 12.49
LV Mass, g	1328	160.8 ± 47.1	477	167.4 ± 51.66	477	163.5 ± 46.42
Sex, male	1328	393 (29.6%)	491	187 (38.1%)	496	175 (35.3%)
Smoker	1328	188 (14.2%)	491	78 (15.9%)	496	79 (15.9%)
Diabetic	1328	387 (29.1%)	491	150 (30.5%)	496	144 (29.0%)
LV Hypertrophy	1328	210 (15.8%)	491	90 (18.3%)	.496	81 (16.3%)
Hypertensive	1328	1,046 (78.8%)	491	400 (81.5%)	496	391 (78.8%)
Use anti-hypertensive medication	1328	930 (70.0%)	491	357 (72.7%)	496	344 (69.4%)

BMI = body mass index, SBP = systolic blood pressure, DBP = diastolic blood pressure, LV = left ventricular
Smoker: Self-reported smoker within the past year.
Diabetic: current treatment with insulin or oral agents OR a fasting glucose ≥126 mg/dL.
LV Hypertrophy: sex-specific thresholds; LVMI ≥51 g/m^2.7 for males, LVMI ≥49 g/m^2.7 for females
Hypertensive: previous clinical diagnosis by physician with current anti-hypertensive treatment, OR an average SBP ≥140 mmHG or DBP ≥90 mmHG on the second and third clinic visits.

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