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Table 3 Association of ESR1 haplotypes with hip fractures in women.

From: Haplotypes of intron 4 of the estrogen receptor alpha gene and hip fractures: a replication study in Caucasians

 

Frequency in cases (%)

Frequency in controls (%)

OR (95% CI)

p-value

2-SNP

    

CG

23.6

20.1

1

-

TG

0.8

1.2

0.54 (0.26-1.16)

0.22

CA

3.0

6.5

0.39 (0.26-0.59)

1.8 × 10-5

TA

72.6

72.2

0.85 (0.70-1.0)

0.77

3-SNP

    

GCG

14.7

13.5

1

-

CCG

8.9

6.8

1.18 (0.83-1.69)

0.05

CTG

0.8

1.2

0.58 (0.27-1.25)

0.22

GCA

0.6

3.2

0.17 (0.08-0.37)

8.6 × 10-7

CCA

2.4

3.3

0.67 (0.4-1.13)

0.13

GTA

1.4

1.9

0.65 (0.32-1.31)

0.26

CTA

71.2

70.1

0.92 (0.73-1.17)

0.52

  1. 2-SNP haplotypes include rs3020314 and rs1884051
  2. 3-SNP haplotypes include rs1801132, rs3020314 and rs1884051