Table 2 Association of 12 SNPs with emphysema
From: Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases
Gene and SNP | Allele | Genotypic frequency in subjects with emphysema (n = 189) MM/Mm/mm | Genotypic frequency in subjects without emphysema (n = 1146) MM/Mm/mm | p value for HWE | p value for minor allele carriers* | p value for minor allele homozygotes* |
|---|---|---|---|---|---|---|
SERPINA1 | Â | Â | Â | Â | Â | Â |
   rs8004738 | A/G | .26/.50/.24 | .24/.51/.25 | .873 | .761 | .459 |
   rs17751769 | A/G | .26/.50/.24 | .24/.50/.26 | .858 | .902 | .573 |
   rs709932 | G/A | .53/.40/.07 | .56/.37/.07 | .450 | .439 | .866 |
   rs1303 | A/C | .47/.42/.11 | .51/.40/.09 | .896 | .275 | .572 |
   rs11832 | A/G | .45/.42/.13 | .49/.40/.11 | .148 | .217 | .416 |
SERPINA3 | Â | Â | Â | Â | Â | Â |
   rs4934 | A/G | .37/.44/.19 | .35/.47/.18 | .440 | .699 | .910 |
SERPINE2 | Â | Â | Â | Â | Â | Â |
   rs840088 | C/T | .32/.49/.19 | .35/.48/.17 | .928 | .699 | .908 |
   rs975278 | A/G | .26/.47/.27 | .29/.52/.19 | .329 | .175 | .037 |