Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

BMC Medical Genetics

Table 4 Analysis of combined sets under various models

Genotype and allele frequencies of RAGE gene polymorphism rs2070600 in the exploratory and confirmatory sets combined:
Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio (95% CI)	P
RAGE	rs2070600	G	95.4%	92%	1.8 (1.2 -2.7)	0.003²	SNP		0.003²
		A	4.6%	8%	0.55 (0.37-0.82)		Dominant	0.51 (0.34 - 0.77)¹	0.0013²
							Additive	R = -0.0997	0.003³
*Genotype and allele frequencies of RAGE in all sets combined:**
Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio/R (95% CI)	P
RAGE	rs2070600	G	95.2%	91.4%	1.78 (1.22 -2.60)	0.0003*	SNP		0.0003²
		A	4.8%	8.6%	0.54 (0.38-0.76)		Dominant	0.49 (0.34 - 0.70)¹	0.00011²
							Additive A	R = -0.10548	0.00047³

*includes the exploratory, confirmatory sets and that of Kumaramanickavel et al.
¹(AA,AG)/AA
²χ², P-Value < 0.05 is considered to be statistically significant.
³Trend, P-Value < 0.05 is considered to be statistically significant (not corrected for multiple testing).

ISSN: 1471-2350