Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

BMC Medical Genetics

Table 3 Analysis of RAGE under various models in the exploratory and confirmatory sets

Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio (95% CI)	P
RAGE	rs2070600	G	95.1%	91.9%	1.7 (1.1 -2.6)	0.016²	SNP		0.04²
		A	4.9%	8.1%	0.59 (0.38-0.91)		Dominant	OR = 0.56 (0.35 - 0.89)¹	0.012²
							Additive	R = -0.091	0.016³
¹(AA,AG)/AA ²χ², P-Value < 0.05 is considered to be statistically significant. ³Trend, P-Value < 0.05 is considered to be statistically significant.
Genotype and allele frequencies of RAGE in the confirmatory set:
Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio/R (95% CI)	P
RAGE	rs2070600	G	96.5%	92.2%	1.78 (1.22 -2.60)	0.068	SNP		0.035²
		A	3.5%	7.8%	0.54 (0.38-0.76)		Dominant	OR = 0.34 (0.13 - 0.94)¹	0.032²
							Additive A	R = -0.129	0.07³

*includes the exploratory, confirmatory sets and that of Kumaramanickavel et al.
¹(AA,AG)/AA
²χ², P-Value < 0.05 is considered to be statistically significant.
³Trend, P-Value < 0.05 is considered to be statistically significant (not corrected for multiple testing).

ISSN: 1471-2350