Table 2 Allele and Genotype distribution of Nine candidate gene polymorphisms in the study

RAGE

(-374 T/A)

T

98.10%

98.52%

0.77 (0.27-2.15)

0.62

TT

96.21%

97.05%

0.76 (0.27-2.13)

0.62

A

1.89%

1.48%

TA

3.79%

2.95%

1.29 (0.46-3.63)

0.62

(- 429T/C)

T

86.26%

83.76%

1.22 (0.84-1.76)

0.29

TT

74.88%

71.31%

1.19 (0.78-1.82)

0.39

C

13.74%

16.24%

TC

22.75%

24.89%

0.88 (0.57-1.37)

0.59

CC

2.37%

3.80%

0.61 (0.20-1.86)

0.38

rs2070600

G

95.1%

91.9%

1.7 (1.1-2.6)

GG

90.4%

84.1%

1.78 (1.13- 2.82)

0.012*

A

4.9%

8.1%

GA

9.3%

15.6%

0.55 (0.35-0.88)

0.011*

AA

0.3%

0.3%

1.04 (0.06 -16.7)

0.97*

PEDF

rs12150053

T

77.86%

76.06%

1.10 (0.80-1.51)

0.52

TT

60.95%

58.12%

1.12 (0.76 -1.64)

0.54

C

22.14%

23.94%

TC

33.81%

35.90%

0.91 (0.61-1.34)

0.64

CC

5.24%

5.98%

1.04 (0.06-1.95)

0.73

rs12948385

G

78.33%

80.17%

0.89 (0.64-1.23)

0.49

GG

62.38%

66.67%

0.82 (0.56-1.22)

0.34

A

21.67%

19.83%

GA

31.90%

27%

1.26 (0.84-1.90)

0.25

AA

5.71%

6.33%

0.89 (0.40-1.96)

0.78

rs58697961

G

50.47%

51.90%

0.94 (0.72-1.22)

0.67

GG

27.01%

26.58%

1.02 (0.67-1.55)

0.91

A

49.53%

48.10%

GA

46.92%

50.63%

0.86 (0.59-1.24)

0.43

AA

26.07%

22.78%

1.19 (0.77-1.84)

0.41

rs1136287

C

58.17%

54.03%

1.18 (0.90-1.54)

0.21

CC

34.13%

28.40%

1.30 (0.87-1.95)

0.19

T

41.83%

45.97%

CT

48.08%

51.27%

0.88 (0.60-1.27)

0.5

TT

17.79%

20.33%

0.84 (0.52-1.36)

0.49

HTRA1

rs11200638

G

61.7%

70%

0.68 (0.45-1.01)

0.055

GG

39.34%

47.68%

0.64 (0.37-1.1)

0.11

A

38.3%

30.0%

GA

46.92%

43.04%

1.18 (0.69-2.04)

0.53

AA

13.74%

9.28%

1.86 (0.8-4.3)

0.14

EPO

rs1617640

G

67.30%

67.72%

0.98 (0.74 -1.29)

0.89

GG

43.60%

43.88%

0.98 (0.68-1.43)

0.95

T

32.70%

32.28%

GT

47.39%

47.68%

0.98 (0.68-1.43)

0.95

TT

9%

8.44%

1.07 (0.55-2.07)

0.83

ICAM

rs5498

A

53.42%

51.91%

1.06 (0.81-1.39)

0.66

AA

30%

27.66%

1.12 (0.73-1.70)

0.59

G

46.58%

48.08%

AG

46.84%

48.51%

0.93 (0.63-1.37)

0.73

GG

23.16%

23.83%

0.96 (0.61-1.51)

0.87

CFH

rs3753394

T

72.03%

69.49%

1.13 (0.83-1.53)

0.42

TT

55.36%

49.15%

1.28 (0.86-1.89)

0.21

C

27.97%

30.51%

CT

33.33%

40.68%

0.72 (0.48-1.09)

0.12

CC

11.30%

10.17%

1.12 (0.60-2.10)

0.71

rs1061170

C

69.86%

72.25%

0.89 (0.66 - 1.19)

0.43

CC

48.33%

50%

0.93 (0.64-1.35)

0.72

T

30.14%

27.75%

CT

43.06%

44.49%

0.94 (0.64-1.37)

0.76

TT

8.61%

5.50%

1.61 (0.77-3.38)

0.19

rs10490924

T

62.57%

68.43%

0.77 (0.57 - 1.02)

0.07

TT

38.55%

47.03%

0.08

G

37.43%

31.57%

TG

48.04%

42.80%

1.23 (0.83 - 1.82)

0.28

GG

13.41%

10.17%

1.36 (0.74 - 2.49)

0.3