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Table 3 Univariate multivariable-adjusteda multipoint linkage (LOD ≥ 2.0) at chromosomal regions with obesity-related traits.

From: Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population

Sample

Position

Traitb

Peak LOD score

Marker closest to peak LOD score

Genetic map distance of marker (cM)c

Physical map position of marker (bp)d

Marker interval of marker closest to peak LOD score

Physical map position of marker interval (bp)d

Nearest gene on genome to marker

Physical map position of nearest gene on genome (bp)

Nearest gene previously reported with trait

Physical position of nearest gene previously reported with trait (bp)d

Pre-menopausal

1q21

WHR

2.09

D1S498

143.75

149,568,120

D1S252-D1S484

117,358,294-159,034,332

PI4KB

149,531,037

LYPLAL1 e

217,413,846

           

RASAL2 e

176,330,253

 

2p21-p22

BMI

2.89

D2S2259

68.78

42,850,051

D2S367-D2S391

34,294,652-46,265,269

HAAO

42,847,734

TMEM18 e

657,975

 

3p26

BMI

2.90

D3S1297

14.83

2,013,403

D3S1297-D3S1304

2,013,403-6,894,583

CNTN4

2,117,247

GHRL f

PPARG f

10,302,434 12,304,349

 

3p26

BMI

2.90

D3S1304

14.83

6,894,242

D3S1297-D3S1263

2,013,403-11,492,535

GRM7

6,877,927

GHRL f

PPARG f

10,302,434 12,304,349

 

13q13

HC

2.87

D13S218

34.15

37,930,231

D3S2338-D3S1266

16,824,399-27,932,698

UFM1

37,822,018

HTR2A f

46,305,514

 

13q14

BMI

2.60

D13S263

44.42

40,978,920

D13S218-D13S153

37,930,231-47,789,009

C13orf15 (RGC32)

40,929,712

HTR2A f

46,305,514

 

13q14

BMI

2.60

D13S153

44.42

47,788,735

D13S263-D13S156

40,978,920-73,555,776

RB1

47,775,884

HTR2A f

46,305,514

Post-menopausal

4p15.3

HC

2.70

D4S403

25.0

13,359,926

D4S2935-D4S419

6,611,782-18,458,207

BOD1L

13,179,464

GNPDA2 e

44,398,926

 

5q21

HC

2.01

D5S433

115.1

103,990,522

D5S644-D5S2027

95,838,450-111,173,613

None g

 

CARTPT f NR3C1 f ADRB2 f

71,050,750 142,637,689 148,186,349

 

5q22

HC

2.01

D5S2027

115.1

111,173,318

D5S433-D5S471

103,990,522-119,077,177

STARD4

110,861,921

CARTPT f NR3C1 f ADRB2 f

71,050,750 142,637,689 148,186,349

 

14q13

HC

2.51

D14S70

34.15

33,528,945

D14S275-D14S288

25,766,613-43,171,795

EGLN3

33,463,174

ESR2 f

30,234,561

  1. aAdjusted for age, parity, education, smoking, physical activity, and oophorectomy. BMI was included in the models of waist circumference and WHR, and of hip circumference and WHR.
  2. bBMI, body mass index; WHR, waist to hip ratio; HC, hip circumference.
  3. cGenetic map distance in centimorgans (cM) is the position of genetic markers relative to each other along a chromosome in terms of recombination frequency, rather than as specific physical distance. One cM represents approximately 1% recombination frequency. The greater the recombination frequency between two genetic markers along a chromosome, the farther apart physically they are assumed to be.
  4. dHapMap Genome Browser, NCBI Build 36.
  5. eFrom genome-wide association studies.
  6. fFrom linkage studies.
  7. gNone within 500 kb.
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BMC Medical Genetics

ISSN: 1471-2350

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